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Abstract：
BACKGROUND: Malignancy of the nose and paranasal sinuses is a highly heterogeneous tumor group that arises from various cell types commonly seen in the fifth to sixth decades of life, with twice as much commonness in males. Patients present with varied clinical presentations like nasal obstruction, facial swelling, orbital complications, etc. Squamous cell carcinoma and adenocarcinoma are the most common variant. Surgery followed by adjuvant chemo or radiotherapy is the treatment of choice.
METHODS: The study was undertaken in the Department of Otorhinolaryngology All India Institute of Medical Sciences, Bhopal, India, from 2021 to 2023. It was a retrospective study in which patients diagnosed and underwent treatment in the last 2 years were enrolled. Data were retrieved from the medical record department and surgical registry. Twenty-eight patients were recruited for the study. Detailed history, clinical examination, imaging findings, surgical plans, postoperative adjuvant therapy details, and histopathological findings were recorded.
RESULTS: There were 18 (64.2%) males and 10 (35.8%) females, with a male-to-female ratio of 1.8: 1. The mean age of patients was 50.5 years. Facial swelling was the most frequent symptom (n=15, 54%). Twenty-one (75%) patients use chewable tobacco, while sixteen (57%) are smokers. All our patients belong to the lower socioeconomic group. Endoscopic resection was done in 15 (62.5%) patients, and combined open and endoscopic approaches were used in 9 (37.5%) patients. The most common histological variant was squamous cell carcinoma (n=8, 28%).
CONCLUSIONS: Malignancy of the nose and paranasal sinus is very rare. They presented with varied masked clinical presentations of benign diseases. Early identification and high clinical suspicion, along with imaging studies, are pivotal in managing malignancy of the nose and paranasal sinuses.
METHODS: The study was undertaken in the Department of Otorhinolaryngology All India Institute of Medical Sciences, Bhopal, India, from 2021 to 2023. It was a retrospective study in which patients diagnosed and underwent treatment in the last 2 years were enrolled. Data were retrieved from the medical record department and surgical registry. Twenty-eight patients were recruited for the study. Detailed history, clinical examination, imaging findings, surgical plans, postoperative adjuvant therapy details, and histopathological findings were recorded.
RESULTS: There were 18 (64.2%) males and 10 (35.8%) females, with a male-to-female ratio of 1.8: 1. The mean age of patients was 50.5 years. Facial swelling was the most frequent symptom (n=15, 54%). Twenty-one (75%) patients use chewable tobacco, while sixteen (57%) are smokers. All our patients belong to the lower socioeconomic group. Endoscopic resection was done in 15 (62.5%) patients, and combined open and endoscopic approaches were used in 9 (37.5%) patients. The most common histological variant was squamous cell carcinoma (n=8, 28%).
CONCLUSIONS: Malignancy of the nose and paranasal sinus is very rare. They presented with varied masked clinical presentations of benign diseases. Early identification and high clinical suspicion, along with imaging studies, are pivotal in managing malignancy of the nose and paranasal sinuses.
摘要：
背景：鼻和鼻旁窦的恶性肿瘤是一种高度异质性的肿瘤组，起源于五到六十年生命中常见的各种细胞类型，在男性中有两倍的普遍性。患者表现出不同的临床表现，如鼻塞，面部肿胀,眼眶并发症,等。鳞状细胞癌和腺癌是最常见的变异。手术后辅助化疗或放疗是治疗的选择。
方法：这项研究是在全印度医学科学研究所耳鼻咽喉科进行的，博帕尔,印度,从2021年到2023年。这是一项回顾性研究，纳入了最近2年诊断和接受治疗的患者。从病历部门和手术登记处检索数据。招募了28名患者进行研究。详细的历史,临床检查,影像学发现，手术计划,术后辅助治疗细节，并记录组织病理学结果。
结果:男性18例(64.2%),女性10例(35.8%),男女比例为1.8:1。患者的平均年龄为50.5岁。面部肿胀是最常见的症状（n=15，54％）。21名（75％）患者使用咀嚼型烟草，16人（57%）是吸烟者。我们所有的患者都属于较低的社会经济群体。15例（62.5%）患者行内镜切除，9例(37.5%)患者采用开放和内镜联合入路。最常见的组织学变异是鳞状细胞癌（n=8，28％）。
结论：鼻和鼻旁窦的恶性肿瘤非常罕见。他们提出了良性疾病的各种掩盖临床表现。早期识别和高度临床怀疑，随着成像研究，在治疗鼻和鼻旁窦恶性肿瘤方面至关重要。
方法：这项研究是在全印度医学科学研究所耳鼻咽喉科进行的，博帕尔,印度,从2021年到2023年。这是一项回顾性研究，纳入了最近2年诊断和接受治疗的患者。从病历部门和手术登记处检索数据。招募了28名患者进行研究。详细的历史,临床检查,影像学发现，手术计划,术后辅助治疗细节，并记录组织病理学结果。
结果:男性18例(64.2%),女性10例(35.8%),男女比例为1.8:1。患者的平均年龄为50.5岁。面部肿胀是最常见的症状（n=15，54％）。21名（75％）患者使用咀嚼型烟草，16人（57%）是吸烟者。我们所有的患者都属于较低的社会经济群体。15例（62.5%）患者行内镜切除，9例(37.5%)患者采用开放和内镜联合入路。最常见的组织学变异是鳞状细胞癌（n=8，28％）。
结论：鼻和鼻旁窦的恶性肿瘤非常罕见。他们提出了良性疾病的各种掩盖临床表现。早期识别和高度临床怀疑，随着成像研究，在治疗鼻和鼻旁窦恶性肿瘤方面至关重要。
