UNASSIGNED: Among 152 randomized patients with a mean of 49.5 years, and 99 (65.1%) of them being male, 149 were divided into two groups for subsequent analysis. The remifentanil group (Group R, n = 74) received a 0.5μg kg-1 remifentanil infusion followed by a 0.05μg kg-1 min-1 infusion until 15 minutes, after the onset of agitation. The propofol group (Group P, n = 75) received a 1mg kg-1 propofol infusion once agitation occurred. Emergence agitation was assessed using the Riker Sedation Agitation Score, with a score of ≥5 defining emergence agitation. During the post-anesthesia care unit (PACU), the recurrence of emergence agitation, time to extubation, and discharge from PACU were evaluated.
UNASSIGNED: The incidence of reoccurring emergence agitation was lower in Group R (29.7%) compared with Group P (49.3%), with an odds ratio of 0.44 (95% CI 0.22-0.85; P=0.014). The time to extubation was shorter in Group R (mean 12min, range 8-15 min) compared with Group P (mean 17min, range 13-21 min) (P<0.001), as was the time discharge from the PACU (mean 30.5 min, range 25-40 min) vs Group P (mean 37.5 min, range 31-50 min) (P=0.001).
UNASSIGNED: Treatment of emergence agitation in adults with remifentanil infusion is more effective than propofol, with a shorter time to extubation and discharge from PACU.
■在平均49.5年的152名随机患者中,其中99人(65.1%)是男性,149人分为两组进行后续分析。瑞芬太尼组(R组,n=74)接受0.5μgkg-1瑞芬太尼输注,然后进行0.05μgkg-1min-1输注,直至15分钟,在激动开始后。丙泊酚组(P组,n=75)一旦发生躁动,就接受1mgkg-1异丙酚输注。使用Riker镇静激动评分评估出现的躁动,评分≥5,定义出现躁动。在麻醉后监护病房(PACU)期间,出现躁动的复发,拔管时间,并对PACU的出院情况进行了评估。
■与P组(49.3%)相比,R组(29.7%)的复发躁动发生率较低,比值比为0.44(95%CI0.22-0.85;P=0.014)。R组拔管时间较短(平均12min,范围8-15分钟)与P组(平均17分钟,范围13-21分钟)(P<0.001),从PACU排出的时间(平均30.5分钟,范围25-40分钟)与P组(平均37.5分钟,范围31-50分钟)(P=0.001)。
■瑞芬太尼输注治疗成人苏醒期躁动比丙泊酚更有效,从PACU拔管和排出的时间较短。