Abstract：
Radiotherapy plays a pivotal role in the control and eradication of tumors, but it can also induce radiation injury to surrounding normal tissues while targeting tumor cells. In recent years, FLASH-Radiotherapy (FLASH-RT) has emerged as a cutting-edge research focus in the field of radiation therapy. By delivering high radiation doses to the treatment target in an ultra-short time, FLASH-RT produces the FLASH effect, which reduces the toxicity to normal tissues while achieving comparable tumor control efficacy to conventional radiotherapy. This review provides a brief overview of the development history of FLASH-RT and its impact on tumor control. Additionally, it focuses on introducing the protective effects and molecular mechanisms of this technology on various normal tissues, as well as exploring its synergistic effects when combined with other tumor therapies. Importantly, this review discusses the challenges faced in translating FLASH-RT into clinical practice and outlines its promising future applications.
摘要：
放射治疗在肿瘤的控制和根除中起着举足轻重的作用,但它也可以在靶向肿瘤细胞的同时诱导对周围正常组织的辐射损伤。近年来,FLASH-放射治疗（FLASH-RT）已成为放射治疗领域的前沿研究热点。通过在超短的时间内向治疗目标提供高辐射剂量，FLASH-RT产生FLASH效果，这降低了对正常组织的毒性，同时实现了与常规放射治疗相当的肿瘤控制功效。本文就FLASH-RT的发展历史及其对肿瘤控制的影响作一综述。此外,它重点介绍了该技术对各种正常组织的保护作用和分子机制，以及探索其与其他肿瘤疗法结合时的协同作用。重要的是,这篇综述讨论了将FLASH-RT转化为临床实践所面临的挑战，并概述了其有希望的未来应用。
