Abstract：
This is a protocol for an overview to summarize the findings of Systematic Reviews (SR) dealing with Photodynamic Inactivation (PDI) for control of oral diseases. Specific variables of oral infectious will be considered as outcomes, according to dental specialty. Cochrane Database of Systematic Reviews (CDSR), MEDLINE, LILACS, Embase, and Epistemonikos will be searched, as well as reference lists. A search strategy was developed for each database using only terms related to the intervention (PDI) aiming to maximize sensitivity. After checking for duplicate entries, selection of reviews will be performed in a two-stage technique: two authors will independently screening titles and abstracts, and then full texts will be assessed for inclusion/exclusion criteria. Any disagreement will be resolved through discussion and/or consultation with a third reviewer. Data will be extracted following the recommendations in Chapter V of Cochrane Handbook and using an electronic pre-specified form. The evaluation of the methodological quality and risk of bias (RoB) of the SR included will be carried out using the AMSTAR 2 and ROBIS. Narrative summaries of relevant results from the individual SR will be carried out and displayed in tables and figures. A specific summary will focus on PDI parameters and study designs, such as the type and concentration of photosensitizer, pre-irradiation time, irradiation dosimetry, and infection or microbiological models, to identify the PDI protocols with clinical potential. We will summarize the quantitative results of the SRs narratively.
摘要：
这是一个概述的协议，总结了处理光动力失活（PDI）控制口腔疾病的系统评论（SR）的发现。口腔感染的特定变量将被视为结果，根据牙科专业。Cochrane系统评价数据库(CDSR)，MEDLINE,LILACS,Embase,Epistemonikos将被搜查,以及参考列表。为每个数据库开发了搜索策略，仅使用与干预（PDI）相关的术语，旨在最大程度地提高灵敏度。检查重复条目后，评论的选择将以两阶段的技术进行：两位作者将独立筛选标题和摘要，然后将评估全文的纳入/排除标准。任何分歧将通过讨论和/或与第三审稿人协商解决。数据将根据Cochrane手册第五章中的建议并使用电子预先指定的表格进行提取。将使用AMSTAR2和ROBIS对纳入的SR的方法学质量和偏倚风险（RoB）进行评估。将对各个SR的相关结果进行叙述摘要，并在表格和图形中显示。一个具体的总结将集中在PDI参数和研究设计，例如光敏剂的类型和浓度，预照射时间,辐照剂量测定法，和感染或微生物模型，以确定具有临床潜力的PDI方案。我们将对SRs的定量结果进行叙述总结。
