Abstract：
Pain is one of the key non-motor symptoms experienced by a large proportion of people living with Parkinson\'s disease (PD), yet the mechanisms behind this pain remain elusive and as such its treatment remains suboptimal. It is hoped that through the study of animal models of PD, we can start to unravel some of the contributory mechanisms, and perhaps identify models that prove useful as test beds for assessing the efficacy of potential new analgesics. However, just how far along this journey are we right now? Is it even possible to model pain in PD in animal models of the disease? And have we gathered any insight into pain mechanisms from the use of animal models of PD so far? In this chapter we intend to address these questions and in particular highlight the findings generated by others, and our own group, following studies in a range of rodent models of PD.
摘要：
疼痛是大部分帕金森病（PD）患者所经历的关键非运动症状之一。然而，这种疼痛背后的机制仍然难以捉摸，因此其治疗仍然不理想。希望通过对PD动物模型的研究,我们可以开始解开一些贡献机制，并可能确定证明可用作评估潜在新型镇痛药疗效的试验台的模型。然而,我们现在在这段旅程中走了多远？甚至有可能在疾病的动物模型中模拟PD中的疼痛吗？到目前为止，我们是否从使用PD的动物模型中收集了对疼痛机制的任何见解？在本章中，我们打算解决这些问题，并特别强调其他人产生的发现，和我们自己的团队，以下一系列PD啮齿动物模型的研究。
