Abstract：
The effect of calorie restriction, fasting, and ketogenic diets on the treatment of liver cancer remains uncertain. Therefore, we conducted a systematic review to evaluate the effect of restrictive diets on the development and progression of liver cancer in animal models. We did a meta-analysis using the Cochrane Collaboration\'s Review Manager software, with the random effects model and the inverse variance technique. We examined 19 studies that were conducted between 1983 and 2020. Of these, 63.2% investigated calorie restriction, 21.0% experimented with a ketogenic diet, and 15.8% investigated the effects of fasting. The intervention lasted anything from 48 h to 221 weeks. Results showed that restrictive diets may reduce tumor incidence and progression, with a significant reduction in the risk of liver cancer development. Thereby, our results suggest that putting limits on what you eat may help treat liver cancer in more ways than one.
摘要：
热量限制的影响，禁食,生酮饮食对肝癌的治疗仍不确定。因此,我们进行了系统评价,目的是在动物模型中评价限制性饮食对肝癌发生发展的影响.我们使用CochraneCollaboration的ReviewManager软件进行了荟萃分析，随机效应模型和逆方差技术。我们检查了1983年至2020年之间进行的19项研究。其中,63.2%的卡路里限制调查，21.0%的人尝试生酮饮食，15.8%调查了禁食的影响。干预持续了48小时到221周。结果表明，限制性饮食可以减少肿瘤的发病率和进展，与肝癌发展的风险显着降低。因此，我们的研究结果表明，限制你吃什么可能有助于治疗肝癌的方式不止一个。
