Abstract：
Preschool children with wheezing disorders pose diagnostic and therapeutic challenges and consume substantial healthcare resources. Peripheral eosinophil blood count (EBC) has been proposed as a potential indicator for future asthma development. This review by the European Academy of Allergy and Clinical Immunology (EAACI) Preschool Wheeze Task Force aimed to provide systematic evidence for the association between increased EBC and the risk of future asthma, as well as to identify potential cutoff values. In February 2023, a search of PubMed, EMBASE, and Cochrane Library databases was conducted to identify studies comparing EBCs in preschool children with wheezing who continued to wheeze later in life and those who did not. Included observational studies focused on children aged <6 years with a wheezing disorder, assessment of their EBCs, and subsequent asthma status. No language or publication date restrictions were applied. Among the initial 3394 studies screened, 10 were included in the final analysis, involving 1225 patients. The data from these studies demonstrated that high EBC in preschool children with wheezing is associated with future asthma development, with odds ratios of 1.90 (95% CI: 0.45-7.98, p = .38), 2.87 (95% CI: 1.38-5.95, p < .05), and 3.38 (95% CI: 1.72-6.64, p < .05) for cutoff values in the <300, 300-449, and ≥450 cells/μL ranges, respectively. Defining a specific cutoff point for an elevated EBC lacks consistency, but children with EBC >300 cells/μL are at increased risk of asthma. However, further research is needed due to the limitations of the included studies. Future investigations are necessary to fully elucidate the discussed association.
摘要：
患有喘息障碍的学龄前儿童构成诊断和治疗挑战，并消耗大量的医疗保健资源。外周嗜酸性粒细胞血细胞计数（EBC）已被提出作为未来哮喘发展的潜在指标。欧洲过敏和临床免疫学学会（EAACI）学龄前Wheze工作组的这篇综述旨在为EBC升高与未来哮喘风险之间的关联提供系统证据。以及确定潜在的临界值。2023年2月，搜索PubMed，EMBASE,和CochraneLibrary数据库进行了研究,以确定比较有喘息的学龄前儿童的EBC,这些儿童在以后的生活中继续喘息和没有喘息的人。纳入的观察性研究集中于年龄小于6岁的喘息障碍儿童，评估他们的EBCs，以及随后的哮喘状态。没有语言或发布日期限制。在最初的3394项研究中，最终分析包括10个，涉及1225名患者。这些研究的数据表明，学龄前儿童喘息的高EBC与未来哮喘的发展有关。比值比为1.90(95%CI：0.45-7.98，p=0.38)，2.87（95%CI：1.38-5.95，p<0.05），对于<300、300-449和≥450个细胞/μL范围内的截止值，和3.38（95％CI：1.72-6.64，p<.05），分别。为升高的EBC定义特定的截止点缺乏一致性，但EBC>300细胞/μL的儿童患哮喘的风险增加。然而,由于纳入研究的局限性,需要进一步研究.未来的调查对于充分阐明所讨论的关联是必要的。
