PDF(Pubmed)
Abstract：
The primary objective of this meta-analysis was to provide the comprehensive understanding of the intricate correlation that existed between immune senescence and its effects on the advancement of lung cancer as well as recovery of cutaneous wounds. By conducting this systematic review of six rigorous studies utilizing databases such as PubMed and Web of Science, this research examined the multitude of facets pertaining to immune aging and consequences it bear on the health outcomes. The incorporated studies encompassed wide range of geographical and methodological viewpoints, with the specific emphasis on non-small-cell lung cancer and diverse scenarios related to wound recovery. This analysis synthesized discoveries regarding therapeutic responses, cellular and molecular mechanisms and impact of lifestyle factors on immune senescence. The findings suggested that immune senescence has substantial impact on the effectiveness of treatments for lung cancer and cutaneous wounds healing process; therefore, targeted therapies and holistic approaches may be able to mitigate these effects. By following the revised PRISMA guidelines, this meta-analysis guarantee thorough and ethically sound methodology for amalgamating pre-existing literature. The study concluded by emphasizing the critical nature of comprehending immune senescence in the context of clinical practice and proposed avenues for further investigation to enhance health results among the elderly.
摘要：
这项荟萃分析的主要目的是全面了解免疫衰老及其对肺癌进展和皮肤伤口恢复的影响之间存在的复杂相关性。通过利用PubMed和WebofScience等数据库对六项严格的研究进行系统的审查，这项研究检查了与免疫老化有关的多个方面及其对健康结果的影响。纳入的研究涵盖了广泛的地理和方法论观点，特别强调非小细胞肺癌和与伤口恢复相关的各种情况。这项分析综合了有关治疗反应的发现，细胞和分子机制以及生活方式因素对免疫衰老的影响。研究结果表明，免疫衰老对肺癌的治疗效果和皮肤伤口愈合过程有重大影响；因此，靶向治疗和整体方法可能能够减轻这些影响。通过遵循修订后的PRISMA准则，这种荟萃分析保证了对现有文献进行合并的全面和道德上合理的方法。该研究最后强调了在临床实践中理解免疫衰老的关键性质，并提出了进一步研究以增强老年人健康结果的途径。
