PDF(Pubmed)
Abstract：
Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple roles in various aspects of neurons, including cell survival and synaptic function. BDNF and its receptor TrkB are extensively expressed in neurons of the central nervous system (CNS), and the contribution of the BDNF/TrkB system to neuronal function is evident; thus, its downregulation has been considered to be involved in the pathogenesis of Alzheimer\'s disease (AD). GCs, stress-related molecules, and glucocorticoid receptors (GRs) are also considered to be associated with AD in addition to mental disorders such as depression. Importantly, a growing body of evidence suggests a close relationship between BDNF/TrkB-mediated signaling and the GCs/GR system in the CNS. Here, we introduce the current studies on the interaction between the neurotrophic system and stress in CNS neurons and discuss their involvement in the pathophysiology of AD.
摘要：
脑源性神经营养因子(BDNF)和糖皮质激素(GCs)在神经元的各个方面发挥着多重作用,包括细胞存活和突触功能。BDNF及其受体TrkB在中枢神经系统（CNS）的神经元中广泛表达，BDNF/TrkB系统对神经元功能的贡献是显而易见的；因此，其下调被认为与阿尔茨海默病(AD)的发病机制有关。GCs,应激相关分子，和糖皮质激素受体（GR）也被认为与AD有关，除了精神障碍，如抑郁症。重要的是,越来越多的证据表明BDNF/TrkB介导的信号传导与CNS中的GCs/GR系统之间存在密切关系。这里,我们介绍了目前关于神经营养系统与中枢神经系统神经元应激之间相互作用的研究，并讨论了它们在AD病理生理学中的作用。
