PDF(Pubmed)
Abstract：
Different protein sources can impact gut microbiota composition and abundance, and also participate in health regulation. In this study, mice were gavaged with yeast protein (YP), soybean protein isolate (SPI), and whey protein isolate (WPI) for 28 days. Body weights showed similar patterns across different protein administration groups. The ileum in YP-supplemented mice exhibited good morphology, and tight-junction (TJ) proteins were slightly upregulated. Immunoglobulin (Ig)A, IgM, and IgG levels in the ileum of different protein groups were significantly increased (p < 0.05). Interleukin (IL)-10 levels were significantly increased, whereas IL-6 levels were significantly reduced in the YP group when compared with the control (C) (p < 0.05). Glutathione peroxidase (GSH-Px) levels in the ileum were significantly increased in the YP group (p < 0.05). These results indicate that YP potentially improved intestinal immunity and inflammatory profiles. The relative abundances of Parabacteroides, Prevotella, and Pseudobutyrivibrio in the YP group were more enriched when compared with the C and SPI groups, and Parabacteroides was significantly upregulated when compared with the WPI group (p < 0.05). Overall, the results indicate that YP upregulates the beneficial bacteria and improves ileal immunity and anti-inflammatory capabilities.
摘要：
不同的蛋白质来源可以影响肠道菌群组成和丰度，并参与卫生监管。在这项研究中,用酵母蛋白（YP）对小鼠进行管饲，大豆分离蛋白(SPI),和乳清蛋白分离物(WPI)28天。体重在不同的蛋白质给药组中显示出相似的模式。补充YP的小鼠回肠表现出良好的形态，和紧密连接（TJ）蛋白略有上调。免疫球蛋白A,IgM,不同蛋白组回肠IgG水平均显著升高(p<0.05)。白细胞介素（IL）-10水平显著升高，而IL-6水平在YP组与对照组相比显著降低(C)(p<0.05)。YP组回肠中谷胱甘肽过氧化物酶(GSH-Px)水平显著升高(p<0.05)。这些结果表明YP可能改善肠道免疫和炎症谱。副杆菌属的相对丰度，普雷沃氏菌,与C和SPI组相比，YP组的假丁酸弧菌更丰富，与WPI组相比，副杆菌明显上调（p<0.05）。总的来说,结果表明，YP上调有益菌，提高回肠免疫力和抗炎能力。
