PDF(Pubmed)
Abstract：
Lung inflammation and alveolar enlargement are the major pathological conditions of chronic obstructive pulmonary disease (COPD) patients. Rice bran oil (RBO), a natural anti-inflammatory and antioxidative agent, has been used for therapeutic purposes in several inflammatory diseases. This study aimed to investigate the anti-inflammatory and antioxidative effect of RBO on a cigarette smoke extract (CSE)-induced emphysema model in mice. The results indicated that CSE significantly induced airspace enlargement in mouse lung. Increased inflammatory cells, macrophage, and TNF-alpha levels in bronchoalveolar lavage fluid (BALF) were noticed in CSE-treated mice. RBO (low and high dose)-supplemented mice showed decreased total BALF inflammatory cell, macrophage, and neutrophil numbers and TNF-alpha levels (p < 0.05). Additionally, the administration of RBO decreased the mean linear alveolar intercept (MLI) in the CSE-treated group. Additionally, RBO treatment significantly increased the total antioxidant capacity in both mouse BALF and serum. However, RBO did not have an effect on the malondialdehyde (MDA) level. These findings suggested that RBO treatment ameliorates lung inflammation in a CSE-induced emphysema mice model through anti-inflammatory and antioxidant pathways. Therefore, the supplementation of RBO could be a new potential therapeutic to relieve the severity of COPD.
摘要：
肺部炎症和肺泡肿大是慢性阻塞性肺疾病（COPD）患者的主要病理状况。米糠油（RBO），一种天然的抗炎和抗氧化剂，已用于几种炎性疾病的治疗目的。本研究旨在探讨RBO对香烟烟雾提取物(CSE)诱导的小鼠肺气肿模型的抗炎和抗氧化作用。结果表明，CSE明显引起小鼠肺部空域增大。炎症细胞增多,巨噬细胞,在CSE处理的小鼠中观察到支气管肺泡灌洗液（BALF）中的TNF-α水平。补充RBO（低剂量和高剂量）的小鼠显示总BALF炎症细胞减少，巨噬细胞,中性粒细胞数量和TNF-α水平（p<0.05）。此外,在CSE治疗组中,给予RBO降低了平均线性肺泡截距(MLI).此外,RBO处理显著增加小鼠BALF和血清中的总抗氧化能力。然而,RBO对丙二醛（MDA）水平没有影响。这些发现表明RBO治疗通过抗炎和抗氧化途径改善CSE诱导的肺气肿小鼠模型中的肺部炎症。因此,补充RBO可能是缓解COPD严重程度的一种新的潜在治疗方法.
