PDF(Pubmed)
Abstract：
One continuous companion and one of the major players in the human blood virome are members of the Anelloviridae family. Anelloviruses are probably found in all humans, infection occurs early in life and the composition (anellome) is thought to remain stable and personal during adulthood. The stable anellome implies a great balance between the host immune system and the virus. However, the lack of a robust culturing system hampers direct investigation of interactions between virus and host cells. Other techniques, however, including next generation sequencing, AnelloScan-antibody tests, evolution selection pressure analysis, and virus protein structures, do provide new insights into the interactions between anelloviruses and the host immune system. This review aims at providing an overview of the current knowledge on the immune mechanisms acting on anelloviruses and the countering viral mechanisms allowing immune evasion.
摘要：
人类血液病毒的一个连续伴侣和主要参与者之一是Anelloviridae家族的成员。粘膜病毒可能在所有人类中发现，感染发生在生命的早期，并且该组合物（anellome）被认为在成年期保持稳定和个人。稳定的Anellome意味着宿主免疫系统和病毒之间的巨大平衡。然而,缺乏强大的培养系统阻碍了病毒和宿主细胞之间相互作用的直接研究。其他技术,然而,包括下一代测序，AnelloScan抗体测试,演化选择压力分析，和病毒蛋白质结构，提供新的见解之间的相互作用的anellovirus和宿主的免疫系统。这篇综述旨在概述有关作用于anellovirus的免疫机制和允许免疫逃避的对抗病毒机制的最新知识。
