Abstract：
OBJECTIVE: To compare the effect of povidone-iodine (PI) 5% and moxifloxacin 0.5% solutions versus PI 5% solution alone on the conjunctival bacterial flora.
METHODS: This is a comparative study in which the study population comprised adult patients scheduled for elective small incision cataract surgery. The eye to be operated (control eye) received topical moxifloxacin 0.5% drops 4 times, 1 day before surgery and 2 applications on the day of surgery. As placebo, the contralateral eye (study eye) received saline 0.90% drops as per the same schedule. Before surgery, on table, PI 5% was instilled in the conjunctival sac in both eyes. Conjunctival swabs were taken before initiation of therapy and 3 min after instillation of PI.
RESULTS: Of the 96 pairs of eyes included in the study, conjunctival cultures before prophylaxis were similar between the two groups (p = 0.31), with 54 samples (56%) of the study group and 49 (51%) of the control group showing growth. With positive cultures reducing to 7 (14%) in the study group and 8 (16%) in the control group, both the prophylaxis methods appeared equally efficacious (p = 0.79). Both the groups showed a significant reduction in positive cultures following prophylaxis (p < 0.0001).
CONCLUSIONS: PI 5% alone as preoperative prophylaxis was as effective as its combination therapy with moxifloxacin 0.5% in the reduction in conjunctival bacterial colonization.
METHODS: This is a comparative study in which the study population comprised adult patients scheduled for elective small incision cataract surgery. The eye to be operated (control eye) received topical moxifloxacin 0.5% drops 4 times, 1 day before surgery and 2 applications on the day of surgery. As placebo, the contralateral eye (study eye) received saline 0.90% drops as per the same schedule. Before surgery, on table, PI 5% was instilled in the conjunctival sac in both eyes. Conjunctival swabs were taken before initiation of therapy and 3 min after instillation of PI.
RESULTS: Of the 96 pairs of eyes included in the study, conjunctival cultures before prophylaxis were similar between the two groups (p = 0.31), with 54 samples (56%) of the study group and 49 (51%) of the control group showing growth. With positive cultures reducing to 7 (14%) in the study group and 8 (16%) in the control group, both the prophylaxis methods appeared equally efficacious (p = 0.79). Both the groups showed a significant reduction in positive cultures following prophylaxis (p < 0.0001).
CONCLUSIONS: PI 5% alone as preoperative prophylaxis was as effective as its combination therapy with moxifloxacin 0.5% in the reduction in conjunctival bacterial colonization.
摘要：
目的：比较5%聚维酮碘（PI）和0.5%莫西沙星溶液与5%单用PI溶液对结膜细菌菌群的影响。
方法：这是一项比较研究，研究人群包括择期小切口白内障手术的成年患者。待手术的眼睛（对照眼）接受了0.5%莫西沙星局部滴剂4次，手术前1天和手术当天2次应用。作为安慰剂，对侧眼(研究眼)按照相同的时间表接受生理盐水0.90%滴剂.手术前,在桌子上,将PI5％滴入双眼的结膜囊中。在开始治疗前和滴注PI后3分钟服用结膜拭子。
结果：在研究中纳入的96对眼睛中，预防前的结膜培养在两组之间相似（p=0.31），研究组的54个样本（56％）和对照组的49个样本（51％）显示生长。阳性培养物在研究组中减少到7（14％），在对照组中减少到8（16％），两种预防方法似乎同样有效(p=0.79).两组均显示预防后阳性培养物显著减少(p<0.0001)。
结论：在减少结膜细菌定植方面，单独作为术前预防的PI5%与莫西沙星0.5%联合治疗同样有效。
方法：这是一项比较研究，研究人群包括择期小切口白内障手术的成年患者。待手术的眼睛（对照眼）接受了0.5%莫西沙星局部滴剂4次，手术前1天和手术当天2次应用。作为安慰剂，对侧眼(研究眼)按照相同的时间表接受生理盐水0.90%滴剂.手术前,在桌子上,将PI5％滴入双眼的结膜囊中。在开始治疗前和滴注PI后3分钟服用结膜拭子。
结果：在研究中纳入的96对眼睛中，预防前的结膜培养在两组之间相似（p=0.31），研究组的54个样本（56％）和对照组的49个样本（51％）显示生长。阳性培养物在研究组中减少到7（14％），在对照组中减少到8（16％），两种预防方法似乎同样有效(p=0.79).两组均显示预防后阳性培养物显著减少(p<0.0001)。
结论：在减少结膜细菌定植方面，单独作为术前预防的PI5%与莫西沙星0.5%联合治疗同样有效。
