RESULTS: In this study, a novel light-addressed potentiometric sensor (LAPS) using silicon-on-sapphire technology, has been successfully developed for Ca2+ sensing. The Ca2+-sensitive LAPS achieved a wide-range detection of Ca2+, ranging from 10-2 M to 10-7 M, with an impressive detection limit of 100 nM. These advancements are attributed to the ultra-thin silicon layer, silicon dioxide layer, and solid-state silicon rubber sensitive membrane around 6 μm. Furthermore, the sensor demonstrated the ability to dynamically monitor fluctuations in Ca2+ concentration ranging from 10-9 M to 10-2 M within a solution. Its remarkable selectivity, specificity, and long-term stability have facilitated its successful application in the detection of Ca2+ in human serum and urine.
UNASSIGNED: This work presents a Ca2+-sensitive sensor that combines a low detection limit and a wide detection range. The development represents the emergence of a label-free and rapid Ca2+ detection tool with immense prospects in home-based health monitoring, community disease screening, as well as cellular metabolism, and drug screening evaluations.
结果:在这项研究中,使用蓝宝石上硅技术的新型光寻址电位传感器(LAPS),已成功开发用于Ca2+传感。Ca2+敏感型LAPS实现了对Ca2+的宽范围检测,范围从10-2M到10-7M,具有令人印象深刻的检测限为100nM。这些进步归功于超薄硅层,二氧化硅层,和6μm左右的固态硅橡胶敏感膜。此外,该传感器展示了动态监测溶液中Ca2+浓度波动的能力,范围从10-9M到10-2M。其显著的选择性,特异性,和长期稳定性促进了其在人血清和尿液中Ca2+检测中的成功应用。
■这项工作提出了一种Ca2敏感的传感器,该传感器结合了低检测极限和宽检测范围。这一发展代表了一种无标签和快速Ca2+检测工具的出现,在基于家庭的健康监测中具有巨大的前景。社区疾病筛查,以及细胞代谢,和药物筛选评估。