Abstract：
Intracranial dural arteriovenous fistulas (IDAVFs) are abnormal vascular connections between dural arteries and various venous structures within the brain. IDAVFs, rarely present with parkinsonism and dementia concurrently, making this a unique and underexplored clinical scenario. To the best of our knowledge, this is the first systematic review to comprehensively analyze cases of IDAVFs manifesting as both parkinsonism and dementia.
We assessed databases from inception to September 18, 2023. We identified studies describing patients with IDAVFs initially presenting with dementia or parkinsonism. Inclusion criteria encompassed case reports and case series, while excluding review articles, guidelines, technical notes, comments, conference abstracts, and editorials.
The systematic search resulted in the initial screening of 383 studies, with 33 articles meeting the inclusion criteria. Among these, 29 were case reports, often describing 3 or fewer patients. From the remaining 4 case series, data pertinent to patients presenting both parkinsonism and dementia were selectively extracted, yielding a total study population of 43 patients. The anatomical distribution of IDAVFs within this cohort was diverse, with the transverse and sigmoid sinuses being the most common locations. Although most of these patients received endovascular therapy, a few underwent microsurgical occlusion or combined surgical and endovascular treatment.
IDAVFs presenting with both parkinsonism and dementia represent a rare clinical entity. This systematic review provides valuable insights into the clinical characteristics, treatment options, and outcomes for such cases. However, additional research involving larger cohorts is essential to better comprehend the underlying mechanisms and establish standardized therapeutic guidelines.
We assessed databases from inception to September 18, 2023. We identified studies describing patients with IDAVFs initially presenting with dementia or parkinsonism. Inclusion criteria encompassed case reports and case series, while excluding review articles, guidelines, technical notes, comments, conference abstracts, and editorials.
The systematic search resulted in the initial screening of 383 studies, with 33 articles meeting the inclusion criteria. Among these, 29 were case reports, often describing 3 or fewer patients. From the remaining 4 case series, data pertinent to patients presenting both parkinsonism and dementia were selectively extracted, yielding a total study population of 43 patients. The anatomical distribution of IDAVFs within this cohort was diverse, with the transverse and sigmoid sinuses being the most common locations. Although most of these patients received endovascular therapy, a few underwent microsurgical occlusion or combined surgical and endovascular treatment.
IDAVFs presenting with both parkinsonism and dementia represent a rare clinical entity. This systematic review provides valuable insights into the clinical characteristics, treatment options, and outcomes for such cases. However, additional research involving larger cohorts is essential to better comprehend the underlying mechanisms and establish standardized therapeutic guidelines.
摘要：
背景：颅内硬脑膜动静脉瘘（IDAVFs）是硬脑膜动脉和脑内各种静脉结构之间的异常血管连接。IDAVF,很少同时出现帕金森病和痴呆，使这成为一个独特且未充分开发的临床场景。据我们所知,这是第一个全面分析同时表现为帕金森病和痴呆的IDAVFs病例的系统综述.
方法：我们评估了从开始到2023年9月18日的数据库。我们确定了描述最初表现为痴呆或帕金森病的IDAVFs患者的研究。纳入标准包括病例报告和病例系列，虽然不包括评论文章，指导方针,技术说明,注释,会议摘要，和社论。
结果：系统搜索导致对383项研究的初步筛选，33篇文章符合纳入标准。其中,29例病例报告，通常描述3个或更少的患者。从剩下的4个案例系列中，有选择地提取与同时出现帕金森病和痴呆的患者相关的数据，产生了43名患者的总研究人群。该队列中IDAVFs的解剖分布是多样的，横窦和乙状窦是最常见的位置。尽管这些患者大多接受了血管内治疗，少数人接受了显微外科封堵术或手术和血管内联合治疗。
结论：表现为帕金森病和痴呆的IDAVFs是一种罕见的临床实体。这篇系统综述提供了对临床特征的有价值的见解，治疗方案,以及此类案件的结果。然而,涉及更大队列的额外研究对于更好地理解潜在机制和建立标准化治疗指南至关重要.
方法：我们评估了从开始到2023年9月18日的数据库。我们确定了描述最初表现为痴呆或帕金森病的IDAVFs患者的研究。纳入标准包括病例报告和病例系列，虽然不包括评论文章，指导方针,技术说明,注释,会议摘要，和社论。
结果：系统搜索导致对383项研究的初步筛选，33篇文章符合纳入标准。其中,29例病例报告，通常描述3个或更少的患者。从剩下的4个案例系列中，有选择地提取与同时出现帕金森病和痴呆的患者相关的数据，产生了43名患者的总研究人群。该队列中IDAVFs的解剖分布是多样的，横窦和乙状窦是最常见的位置。尽管这些患者大多接受了血管内治疗，少数人接受了显微外科封堵术或手术和血管内联合治疗。
结论：表现为帕金森病和痴呆的IDAVFs是一种罕见的临床实体。这篇系统综述提供了对临床特征的有价值的见解，治疗方案,以及此类案件的结果。然而,涉及更大队列的额外研究对于更好地理解潜在机制和建立标准化治疗指南至关重要.
