PDF(Pubmed)
Abstract：
OBJECTIVE: Chronic rhinosinusitis (CRS) is a prevalent chronic disease observed on a global scale. The utilization of endoscopic sinus surgery (ESS) has gained significant recognition as an effective intervention for individuals with CRS and nasal polyps who have not responded to conventional treatments. The need (or not) for revision surgery frequently relies on the promotion of optimal wound healing. The impact of platelet-rich plasma (PRP) on tissue healing has been extensively examined in various surgical fields.
METHODS: The present prospective study involved 30 patients suffering with nasal polyposis who underwent endoscopic sinus surgery. 15 patients were assigned to the PRP group, and 15 patients to the control group. The clinical follow-up of the patients took place at specific intervals, at weeks 1, 2, 3, 4, 8, and 12 after the surgical procedure. The evaluator identified the existence of adhesions, crusting, bleeding, granulation and infection using a visual analogue scale score. The patients also completed the SNOT 22 questionnaire prior to surgery and at each postoperative visit.
RESULTS: The present study observed a lower incidence of adhesion, infection, hemorrhage and granulation in the PRP group. Furthermore, a statistically significant difference was detected between the groups.
CONCLUSIONS: Based on the findings of the present investigation, it seems that platelet-rich plasma (PRP) is beneficial on wound healing during the early stages following the surgical procedure. The technique is characterized by its limited invasiveness, which contributes to its low risk profile and the achievement of clinically good outcomes.
METHODS: The present prospective study involved 30 patients suffering with nasal polyposis who underwent endoscopic sinus surgery. 15 patients were assigned to the PRP group, and 15 patients to the control group. The clinical follow-up of the patients took place at specific intervals, at weeks 1, 2, 3, 4, 8, and 12 after the surgical procedure. The evaluator identified the existence of adhesions, crusting, bleeding, granulation and infection using a visual analogue scale score. The patients also completed the SNOT 22 questionnaire prior to surgery and at each postoperative visit.
RESULTS: The present study observed a lower incidence of adhesion, infection, hemorrhage and granulation in the PRP group. Furthermore, a statistically significant difference was detected between the groups.
CONCLUSIONS: Based on the findings of the present investigation, it seems that platelet-rich plasma (PRP) is beneficial on wound healing during the early stages following the surgical procedure. The technique is characterized by its limited invasiveness, which contributes to its low risk profile and the achievement of clinically good outcomes.
摘要：
目的：慢性鼻-鼻窦炎（CRS）是在全球范围内观察到的一种普遍的慢性疾病。内窥镜鼻窦手术（ESS）的使用已获得了广泛的认可，作为对常规治疗无反应的CRS和鼻息肉患者的有效干预措施。对翻修手术的需要(或不需要)经常依赖于促进最佳的伤口愈合。富血小板血浆（PRP）对组织愈合的影响已在各种手术领域得到广泛研究。
方法：本前瞻性研究涉及30例鼻息肉患者，这些患者接受了鼻内镜手术。15例患者被分配到PRP组，对照组15例。患者的临床随访在特定的时间间隔进行，在外科手术后的第1、2、3、4、8和12周。评估者确定了粘连的存在，结壳,出血,肉芽和感染使用视觉模拟评分。患者还在手术前和每次术后访视时完成了SN0T22问卷。
结果：本研究观察到粘连发生率较低，感染,PRP组出血和肉芽。此外，两组间的差异有统计学意义.
结论：根据本调查的结果，似乎富血小板血浆(PRP)在手术后的早期阶段对伤口愈合有益.该技术的特点是其有限的侵入性，这有助于其低风险状况和临床良好结局的实现。
方法：本前瞻性研究涉及30例鼻息肉患者，这些患者接受了鼻内镜手术。15例患者被分配到PRP组，对照组15例。患者的临床随访在特定的时间间隔进行，在外科手术后的第1、2、3、4、8和12周。评估者确定了粘连的存在，结壳,出血,肉芽和感染使用视觉模拟评分。患者还在手术前和每次术后访视时完成了SN0T22问卷。
结果：本研究观察到粘连发生率较低，感染,PRP组出血和肉芽。此外，两组间的差异有统计学意义.
结论：根据本调查的结果，似乎富血小板血浆(PRP)在手术后的早期阶段对伤口愈合有益.该技术的特点是其有限的侵入性，这有助于其低风险状况和临床良好结局的实现。
