METHODS: The study encompassed 80 female FMS patients and 75 healthy controls. Ultrasound was employed to measure the average ONSD in both groups. Conditions potentially elevating intracranial pressure were ruled out following neurological assessments. Pain (via visual analog scale, VAS), function (revised Fibromyalgia Impact Questionnaire, r-FIQ), QOL (Short Form-36, SF-36), fatigue (fatigue severity scale, FACIT), CS (Central Sensitization Scale), and neuropathic pain (Douleur Neuropathique-4) were evaluated.
RESULTS: The average ONSD was significantly higher in the patient group than the control group. Patients with ONSD >5.5 mm consistent with IIH were categorized as Group 1 (n = 54, 67.5%), while those with a diameter of 5.5 mm and below-formed Group 2. VAS pain (p = .033) and FIQ-R scores (p = .033) were significantly higher in Group 1 than Group 2. Headache was found more common in Group 1.
CONCLUSIONS: This study unveils a substantial occurrence (67.5%) of IIH in FMS patients, suggesting shared pathophysiological mechanisms contributing to symptoms like fatigue, headache, and cognitive dysfunction. Additionally, these findings implicate heightened functional impairment, CS, headache, and fatigue in FMS patients with IIH.
方法:该研究包括80名女性FMS患者和75名健康对照。超声用于测量两组的平均ONSD。神经系统评估后,排除了可能升高颅内压的条件。疼痛(通过视觉模拟量表,VAS),功能(修订后的纤维肌痛影响问卷,r-FIQ),QOL(简表36,SF-36),疲劳(疲劳严重程度量表,FACIT),CS(中央敏感量表),和神经性疼痛(DouleurNeuropathique-4)进行评估。
结果:患者组的平均ONSD明显高于对照组。符合IIH的ONSD>5.5mm的患者被归类为第1组(n=54,67.5%),而直径为5.5毫米及以下的则是第2组。第1组的VAS疼痛(p=.033)和FIQ-R评分(p=.033)明显高于第2组。头痛在第1组中更常见。
结论:这项研究揭示了FMS患者中IIH的大量发生率(67.5%),提示导致疲劳等症状的共同病理生理机制,头痛,和认知功能障碍。此外,这些发现暗示了严重的功能损害,CS,头痛,IIHFMS患者的疲劳。