Abstract：
One new rare carbon-bridged citrinin dimer quinocitrindimer C (1) as a pair of epimers, two new polyketide penicilliodes D (3) and E (4) together with nine known citrinin derivatives, were isolated from the fermentation broth of starfish-derived symbiotic fungus Penicillium sp. GGF16-1-2. Their structures and configurations were elucidated by comprehensively spectroscopic data analysis and electronic circular dichroism calculations. Eleven citrinin derivatives were tested by Colletotrichum gloeosporioides, and compound 2 played a significant antifungal activity against Colletotrichum gloeosporioides with LC50 value of 0.27 μg/ml.
摘要：
一种新的稀有碳桥连的桔霉素二聚体奎宁二聚体C（1）作为一对差向异构体，两种新的聚酮青霉D（3）和E（4）以及九种已知的桔霉素衍生物，从海星衍生的共生真菌青霉的发酵液中分离出来。GGF16-1-2。通过全面的光谱数据分析和电子圆二色性计算阐明了它们的结构和构型。通过炭疽病菌测试了11种桔霉素衍生物，化合物2对炭疽菌具有明显的抗真菌活性，LC50值为0.27μg/ml。
