关键词: Corona virus alkaloid flavonoid natural product phenolic terpenoid

来  源:   DOI:10.1080/14786419.2024.2309322

Abstract:
In this review out of 300 selected articles 70 articles were evaluated, and the most significant compounds impacting COVID-19 and their mechanism of action were introduced. The compounds belong to four categories as follow: Phenolic, Flavonoid, Terpenoid, and Alkaloid compounds. In the phenol groups, the most effective compounds are scutellarin (suppressor of COVID-19 virus), thymol and carvacrol (the most inhibitory effect on COVID-19 virus), in the flavonoid groups, hesperdin (a strong inhibitor on COVID-19), in the terpenoids, methyl tanshinonate and sojil COVID-19 inhibitory effect) and 1,8-cineol (COVID-19 inhibitory effect) and in the last group, niglidine and quinoline alkaloid compounds (COVID-19 inhibitory effect) have been identified and introduced. These compounds have shown promising results due to their structure and effective mechanisms on COVID-19, so it can be an idea for researchers in this field to try to produce drugs by using natural compounds against the COVID-19 and Corona viruses.
摘要:
在这篇综述中,从300篇精选的文章中,对70篇文章进行了评估,并介绍了影响COVID-19的最重要化合物及其作用机制。这些化合物属于以下四类:酚类,类黄酮,萜类,和生物碱化合物。在苯酚基团中,最有效的化合物是灯盏乙素(COVID-19病毒的抑制剂),百里酚和香芹酚(对COVID-19病毒的抑制作用最大),在类黄酮基团中,橙皮丁(COVID-19的强抑制剂),在萜类化合物中,丹参酸甲酯和索吉尔COVID-19抑制作用)和1,8-cineol(COVID-19抑制作用),最后一组,已鉴定并引入了尼克碱和喹啉生物碱化合物(COVID-19抑制作用)。这些化合物由于其结构和对COVID-19的有效机制而显示出有希望的结果,因此该领域的研究人员可以尝试通过使用天然化合物来生产针对COVID-19和冠状病毒的药物。
公众号