PDF(Pubmed)
Abstract：
Chlamydia trachomatis, is a kind of obligate intracellular pathogen. The removal of C. trachomatis relies primarily on specific cellular immunity. It is currently considered that CD4+ Th1 cytokine responses are the major protective immunity against C. trachomatis infection and reinfection rather than CD8+ T cells. The non-specific immunity (innate immunity) also plays an important role in the infection process. To survive inside the cells, the first process that C. trachomatis faces is the innate immune response. As the \"sentry\" of the body, mast cells attempt to engulf and remove C. trachomatis. Dendritic cells present antigen of C. trachomatis to the \"commanders\" (T cells) through MHC-I and MHC-II. IFN-γ produced by activated T cells and natural killer cells (NK) further activates macrophages. They form the body\'s \"combat troops\" and produce immunity against C. trachomatis in the tissues and blood. In addition, the role of eosinophils, basophils, innate lymphoid cells (ILCs), natural killer T (NKT) cells, γδT cells and B-1 cells should not be underestimated in the infection of C. trachomatis. The protective role of innate immunity is insufficient, and sexually transmitted diseases (STDs) caused by C. trachomatis infections tend to be insidious and recalcitrant. As a consequence, C. trachomatis has developed a unique evasion mechanism that triggers inflammatory immunopathology and acts as a bridge to protective to pathological adaptive immunity. This review focuses on the recent advances in how C. trachomatis evades various innate immune cells, which contributes to vaccine development and our understanding of the pathophysiologic consequences of C. trachomatis infection.
摘要：
沙眼衣原体,是一种专性细胞内病原体。沙眼衣原体的去除主要依赖于特异性细胞免疫。目前认为CD4+Th1细胞因子应答是针对沙眼衣原体感染和再感染的主要保护性免疫,而不是CD8+T细胞。非特异性免疫(先天免疫)在感染过程中也起着重要作用。为了在细胞内生存，沙眼衣原体面临的第一个过程是先天免疫反应。作为身体的“哨兵”，肥大细胞试图吞噬和去除沙眼衣原体。树突状细胞通过MHC-I和MHC-II将沙眼衣原体的抗原呈递给“指挥官”（T细胞）。由活化的T细胞和自然杀伤细胞(NK)产生的IFN-γ进一步活化巨噬细胞。它们形成身体的“战斗部队”，并在组织和血液中产生对沙眼衣原体的免疫力。此外,嗜酸性粒细胞的作用，嗜碱性粒细胞,先天淋巴样细胞（ILC），自然杀伤T（NKT）细胞，γδT细胞和B-1细胞在沙眼衣原体感染中不应被低估。先天免疫的保护作用不足,由沙眼衣原体感染引起的性传播疾病（STD）往往是阴险和顽固的。因此,沙眼衣原体已开发出一种独特的逃避机制，可触发炎症免疫病理学，并充当保护病理适应性免疫的桥梁。这篇综述集中在沙眼衣原体如何逃避各种先天免疫细胞的最新进展。这有助于疫苗开发和我们对沙眼衣原体感染的病理生理后果的理解。
