Abstract:
The vaginal microbiota plays a crucial role in female reproductive health and is considered a biomarker for predicting disease outcomes and personalized testing. However, its relationship with human papillomavirus (HPV) infection and cervical cancer is not yet clear. Therefore, this article provides a review of the association between the vaginal microbiota, HPV infection, and cervical cancer. We discuss the composition of the vaginal microbiota, its dysbiosis, and its relationship with HPV infection, as well as potential mechanisms in the development of cervical cancer. In addition, we assess the feasibility of treatment strategies such as probiotics and vaginal microbiota transplantation to modulate the vaginal microbiota for the prevention and treatment of diseases related to HPV infection and cervical cancer. In the future, extensive replication studies are still needed to gain a deeper understanding of the complex relationship between the vaginal microbiota, HPV infection, and cervical cancer, and to clarify the role of the vaginal microbiota as a potential biomarker for predicting disease outcomes, thus providing a theoretical basis for personalized testing.
摘要:
阴道微生物群在女性生殖健康中起着至关重要的作用,被认为是预测疾病结果和个性化测试的生物标志物。然而,其与人乳头瘤病毒(HPV)感染和宫颈癌的关系尚不清楚。因此,本文对阴道微生物群之间的关联进行了综述,HPV感染,还有宫颈癌.我们讨论了阴道微生物群的组成,它的生态失调,及其与HPV感染的关系,以及宫颈癌发展的潜在机制。此外,我们评估了益生菌和阴道微生物移植等治疗策略在预防和治疗HPV感染和宫颈癌相关疾病方面的可行性.在未来,仍然需要进行广泛的复制研究,以更深入地了解阴道微生物群之间的复杂关系,HPV感染,还有宫颈癌,并阐明阴道微生物群作为预测疾病结局的潜在生物标志物的作用,从而为个性化测试提供理论依据。