PDF(Pubmed)
Abstract：
UNASSIGNED: This study was conducted to evaluate and compare the in vitro disinfection efficacies of six commercial lens cleaning and disinfecting products for planned replacement soft contact lenses.
UNASSIGNED: Disinfection efficacies of five multi-purpose solutions (MPSs) and one hydrogen peroxide solution (HPS) as control were evaluated in the presence of organic soil according to the International Organization for Standardization (ISO, Geneva, Switzerland) ISO 14729 stand-alone test protocol. The five specified compendial organisms, three bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens) and two fungi (Candida albicans and Fusarium solani) were incubated with each solution under standard conditions, after which microbes were recovered and quantified.
UNASSIGNED: Each of the solutions evaluated met or exceeded the standard\'s primary criteria (3-log reduction of bacteria and 1-log reduction of fungi) after incubation for the manufacturer-recommended soaking time, except for COMPLETE MPS, which achieved only 0.4 ± 0.1 average log reduction for C. albicans. However, differences in efficacy between the solutions were noted. Average log reduction across all microbes for Biotrue Hydration Plus (4.6 ± 0.1) was comparable to that for CLEAR CARE PLUS HPS (4.3 ± 0.1) and greater than those for OPTI-FREE puremoist (3.6 ± 0.1), OPTI-FREE Replenish (4.0 ± 0.2), ACUVUE RevitaLens (3.9 ± 0.03), and COMPLETE MPS (3.6 ± 0.1). Biotrue Hydration Plus was especially effective at reducing the population of C. albicans (4.2 ± 0.7-log reduction).
UNASSIGNED: Products marketed for planned replacement soft CL disinfection generally meet the ISO 14729 standard\'s primary criteria for reducing populations of compendial organisms, with larger differences between solutions noted with C. albicans.
UNASSIGNED: Disinfection efficacies of five multi-purpose solutions (MPSs) and one hydrogen peroxide solution (HPS) as control were evaluated in the presence of organic soil according to the International Organization for Standardization (ISO, Geneva, Switzerland) ISO 14729 stand-alone test protocol. The five specified compendial organisms, three bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens) and two fungi (Candida albicans and Fusarium solani) were incubated with each solution under standard conditions, after which microbes were recovered and quantified.
UNASSIGNED: Each of the solutions evaluated met or exceeded the standard\'s primary criteria (3-log reduction of bacteria and 1-log reduction of fungi) after incubation for the manufacturer-recommended soaking time, except for COMPLETE MPS, which achieved only 0.4 ± 0.1 average log reduction for C. albicans. However, differences in efficacy between the solutions were noted. Average log reduction across all microbes for Biotrue Hydration Plus (4.6 ± 0.1) was comparable to that for CLEAR CARE PLUS HPS (4.3 ± 0.1) and greater than those for OPTI-FREE puremoist (3.6 ± 0.1), OPTI-FREE Replenish (4.0 ± 0.2), ACUVUE RevitaLens (3.9 ± 0.03), and COMPLETE MPS (3.6 ± 0.1). Biotrue Hydration Plus was especially effective at reducing the population of C. albicans (4.2 ± 0.7-log reduction).
UNASSIGNED: Products marketed for planned replacement soft CL disinfection generally meet the ISO 14729 standard\'s primary criteria for reducing populations of compendial organisms, with larger differences between solutions noted with C. albicans.
摘要：
■进行这项研究，以评估和比较六种商业镜片清洁和消毒产品的体外消毒功效，用于计划更换的软性隐形眼镜。
■根据国际标准化组织（ISO，日内瓦瑞士)ISO14729独立测试协议。五种特定的药典生物，三种细菌(金黄色葡萄球菌，铜绿假单胞菌,和粘质沙雷氏菌）和两种真菌（白色念珠菌和茄病镰刀菌）在标准条件下与每种溶液一起孵育，之后，微生物被回收和定量。
■在培养制造商推荐的浸泡时间后，评估的每种溶液均达到或超过标准的主要标准（细菌减少3-log，真菌减少1-log），除了完整的MPS，白色念珠菌的平均对数减少仅为0.4±0.1。然而,注意到解决方案之间的功效差异。BiotrueHydrationPlus的所有微生物的平均对数减少量（4.6±0.1）与CLEARCAREPLUSHPS的平均对数减少量（4.3±0.1）相当，并且大于OPTI-FREEpuremoist的平均对数减少量（3.6±0.1），无OPTI补充（4.0±0.2），ACUVUERevitaLens(3.9±0.03),并完成MPS（3.6±0.1）。BiotrueHydrationPlus在减少白色念珠菌种群方面特别有效（减少4.2±0.7-log）。
■销售的计划替代软CL消毒产品通常符合ISO14729标准的主要标准，以减少药典生物的数量，与白色念珠菌注意到的解决方案之间的较大差异。
■根据国际标准化组织（ISO，日内瓦瑞士)ISO14729独立测试协议。五种特定的药典生物，三种细菌(金黄色葡萄球菌，铜绿假单胞菌,和粘质沙雷氏菌）和两种真菌（白色念珠菌和茄病镰刀菌）在标准条件下与每种溶液一起孵育，之后，微生物被回收和定量。
■在培养制造商推荐的浸泡时间后，评估的每种溶液均达到或超过标准的主要标准（细菌减少3-log，真菌减少1-log），除了完整的MPS，白色念珠菌的平均对数减少仅为0.4±0.1。然而,注意到解决方案之间的功效差异。BiotrueHydrationPlus的所有微生物的平均对数减少量（4.6±0.1）与CLEARCAREPLUSHPS的平均对数减少量（4.3±0.1）相当，并且大于OPTI-FREEpuremoist的平均对数减少量（3.6±0.1），无OPTI补充（4.0±0.2），ACUVUERevitaLens(3.9±0.03),并完成MPS（3.6±0.1）。BiotrueHydrationPlus在减少白色念珠菌种群方面特别有效（减少4.2±0.7-log）。
■销售的计划替代软CL消毒产品通常符合ISO14729标准的主要标准，以减少药典生物的数量，与白色念珠菌注意到的解决方案之间的较大差异。
