Abstract：
Meningiomas are the most common feline primary brain tumours, and calvarial hyperostosis (CH) is frequently documented in association with this neoplastic entity. The clinical significance of and mechanisms driving the formation of CH in cats with meningiomas are poorly understood, although tumour invasion into the skull and tumour production of cytokines and enzymes have been implicated as causes of CH in humans. This retrospective study investigated relationships between signalment, MRI or CT imaging features, histopathologic tumour characteristics, alkaline phosphatase (ALP) isoenzyme concentrations, tumour expression of matrix metalloproteinases (MMP)-2, MMP-9, and interleukin-6 (IL-6), and progression free survival times (PFS) following surgical treatment in 27 cats with meningiomas with (n = 15) or without (n = 12) evidence of CH. No significant differences in breed, age, sex, body weight, tumour grade, tumour volume, peritumoral edema burden, ALP isoenzyme concentrations, tumour Ki-67 labelling indices or MMP-2 or MMP-9 expression and activity, or PFS were noted between cats with or without CH. There was a trend towards higher serum (p = .06) and intratumoral (p = .07) concentrations of IL-6 in cats with CH, but these comparisons were not statistically significant. Histologic evidence of tumour invasion into bone was observed in 5/12 (42%) with CH and in no (0/6) cats without CH, although this was not statistically significant (p = .07). Tumour invasion into bone and tumour production of IL-6 may contribute to the formation of meningioma associated CH in cats, although larger studies are required to further substantiate these findings and determine their clinical relevance.
摘要：
脑膜瘤是最常见的猫原发性脑肿瘤，和颅骨增生（CH）经常被记录与这种肿瘤实体有关。对脑膜瘤猫中CH形成的临床意义和驱动机制知之甚少，尽管肿瘤侵入颅骨和细胞因子和酶的肿瘤产生被认为是人类CH的原因。这项回顾性研究调查了标志之间的关系，MRI或CT影像特征，组织病理学肿瘤特征，碱性磷酸酶（ALP）同工酶浓度，基质金属蛋白酶（MMP）-2，MMP-9和白介素-6（IL-6）的肿瘤表达，27只患有（n=15）或没有（n=12）CH证据的脑膜瘤猫的手术治疗后的无进展生存期（PFS）。品种没有显著差异，年龄,性别,体重,肿瘤分级,肿瘤体积,瘤周水肿负担，ALP同工酶浓度，肿瘤Ki-67标记指数或MMP-2或MMP-9表达和活性，或PFS记录在有或没有CH的猫之间。在患有CH的猫中，IL-6的血清浓度（p=.06）和肿瘤内浓度（p=.07）有趋势，但这些比较没有统计学意义.在有CH的5/12（42％）和无CH的无（0/6）猫中观察到肿瘤侵入骨骼的组织学证据，尽管这没有统计学意义（p=.07）。肿瘤侵入骨骼和肿瘤产生IL-6可能有助于猫脑膜瘤相关CH的形成，尽管需要更大的研究来进一步证实这些发现并确定其临床相关性。
