Abstract：
Three new griseofulvin derivatives, griseofulvinoside A-C (1-3), were isolated from the ethyl acetate extract of the solid fermentation product of Aureobasidium pullulans. Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR. The antifungal activities of new compounds were evaluated against four phytopathogenic fungi in vitro, and all test compounds demonstrated inhibitory effects. Among them, compound 2 exhibited the most potent activities against the four selected phytopathogenic fungi with inhibitory rates ranging from 40.2 to 75.8% at 0.2 mg/mL.
摘要：
三个新的灰黄霉素衍生物，灰黄菊苷A-C（1-3），从出芽小芽孢杆菌的固体发酵产物的乙酸乙酯提取物中分离。基于对MS的广泛光谱数据分析，阐明了它们的结构，1D和2DNMR。研究了新化合物对4种植物病原真菌的体外抗真菌活性,并且所有测试化合物都表现出抑制作用。其中,化合物2对四种选定的植物病原真菌表现出最有效的活性，在0.2mg/mL时的抑制率为40.2％至75.8％。
