UNASSIGNED: Neurological Pupil index (NPi) from the pupillometry and the SSEP N20 response were registered >48 h after cardiac arrest in comatose survivors. Clinical data were retrospectively analyzed. A receiver operating characteristic curve was used to evaluate the capacity of NPi to predict bilaterally absent SSEP N20 response. An NPi threshold value resulting in <5% false positive rate (FPR) for bilaterally absent N20 response was identified.
UNASSIGNED: From February 2020 to August 2022, we included 54 patients out of which 49 had conclusive pupillometry and SSEP examinations. The NPi threshold value with FPR < 5% was 3.4, yielding 36% sensitivity (95% CI 18-55) and significantly discriminated between respective groups with preserved and bilaterally absent N20 response to SSEP (p-value <0.01).
UNASSIGNED: In this limited cohort, NPi < 3.4 in patients remaining comatose >48 hours after cardiac arrest predicted bilateral loss of the SSEP N20 response with a FPR < 5%. If validated in a larger cohort, an NPi threshold may be clinically applied in settings where SSEP is unavailable.
■在昏迷幸存者心脏骤停后48小时,根据瞳孔测量和SSEPN20反应记录了神经学瞳孔指数(NPi)。对其临床资料进行回顾性分析。接收器工作特性曲线用于评估NPi预测双侧缺乏SSEPN20响应的能力。鉴定了导致双侧不存在N20反应的<5%假阳性率(FPR)的NPi阈值。
■从2020年2月到2022年8月,我们纳入了54例患者,其中49例进行了结论性的瞳孔测量和SSEP检查。FPR<5%的NPi阈值为3.4,灵敏度为36%(95%CI18-55),并且在保留和双侧无N20对SSEP反应的各组之间显着区分(p值<0.01)。
■在这个有限的队列中,在心脏骤停后仍保持昏迷状态>48小时的患者中,NPi<3.4预测SSEPN20反应的双侧丧失,FPR<5%。如果在更大的队列中验证,NPi阈值可在SSEP不可用的环境中临床应用.