PDF(Pubmed)
Abstract：
Shigella typically causes gastrointestinal infections, and extra-intestinal manifestations are rare. We report the first known case of pyogenic cervical spondylitis co-infected with Escherichia coli and Shigella flexneri, highlighting the diagnostic challenges and clinical implications. A 53-year-old woman presented with neck pain for one month. MRI revealed C6 and C7 vertebrae abscesses. The patient underwent anterior cervical debridement and bone-graft fusion. Intraoperative pus culture grew Escherichia coli, while metagenomic next-generation sequencing detected both Escherichia coli and Shigella species. Intravenous imipenem 500 mg every 6 h was administered, leading to full wound healing at a 6-month follow-up. This case emphasizes the importance of considering Shigella infection in the differential diagnosis of pyogenic spondylitis and demonstrates the utility of a multi-pronged diagnostic approach.
摘要：
志贺氏菌通常会引起胃肠道感染，和肠外表现是罕见的。我们报告了第一例已知的化脓性颈椎病合并感染大肠杆菌和福氏志贺氏菌，强调诊断挑战和临床意义。一名53岁的妇女出现颈部疼痛一个月。MRI显示C6和C7椎骨脓肿。该患者接受了颈椎前路清创和植骨融合。术中脓液培养生长大肠杆菌，而宏基因组下一代测序检测到大肠杆菌和志贺氏菌。每6小时静脉注射亚胺培南500毫克，在6个月的随访中导致伤口完全愈合。该病例强调了在化脓性脊柱炎的鉴别诊断中考虑志贺氏菌感染的重要性，并证明了多管齐下的诊断方法的实用性。
