Abstract：
Ambient ionisation mass spectrometry (AIMS) is a form of mass spectrometry whereby analyte ionisation occurs outside of a vacuum source under ambient conditions. This enables the direct analysis of samples in their native state, with little or no sample preparation and without chromatographic separation. The removal of these steps facilitates a much faster analytical process, enabling the direct analysis of samples within minutes if not seconds. Consequently, AIMS has gained rapid popularity across a diverse range of applications, in particular the analysis of drugs and toxins. Numerous fields rely upon mass spectrometry for the detection and identification of drugs, including clinical diagnostics, forensic chemistry, and food safety. However, all of these fields are hindered by the time-consuming and laboratory-confined nature of traditional techniques. As such, the potential for AIMS to resolve these challenges has resulted in a growing interest in ambient ionisation for drug and toxin analysis. Since the early 2000s, forensic science, diagnostic testing, anti-doping, pharmaceuticals, environmental analysis and food safety have all seen a marked increase in AIMS applications, foreshadowing a new future for drug testing. In this review, some of the most promising AIMS techniques for drug analysis will be discussed, alongside different applications of AIMS published over a 5-year period, to provide a summary of the recent research activity for ambient ionisation for drug and toxin analysis.
摘要：
环境电离质谱(AIMS)是质谱的一种形式,由此分析物电离在环境条件下在真空源之外发生。这可以直接分析处于天然状态的样品，几乎没有或没有样品制备，没有色谱分离。这些步骤的删除有助于更快的分析过程，即使不是几秒钟，也可以在几分钟内直接分析样品。因此,AIMS在各种应用程序中迅速普及，特别是对药物和毒素的分析。许多领域依赖于质谱来检测和鉴定药物，包括临床诊断，法医化学,和食品安全。然而,所有这些领域都受到传统技术耗时和实验室限制的阻碍。因此，AIMS解决这些挑战的潜力已导致人们对用于药物和毒素分析的环境电离越来越感兴趣。自2000年代初以来，法医学,诊断测试,反兴奋剂,制药，环境分析和食品安全都看到了AIMS应用的显著增加，预示着药物测试的新未来。在这次审查中,将讨论一些最有前途的药物分析AIMS技术，除了在5年内发布的AIMS的不同应用程序之外，总结了最近用于药物和毒素分析的环境电离研究活动。
