Abstract：
Acute kidney injury (AKI) is defined as an injury to the renal parenchyma, with or without a decrease in kidney function, as reflected by accumulation of uremic toxins or altered urine production (i.e., increased or decreased). AKI might result from any of several factors, including ischemia, inflammation, nephrotoxins, and infectious diseases. AKI can be community- or hospital-acquired. The latter was not previously considered a common cause for AKI in animals; however, recent evidence suggests that the prevalence of hospital-acquired AKI is increasing in veterinary medicine. This is likely due to a combination of increased recognition and awareness of AKI, as well as increased treatment intensity (e.g., ventilation and prolonged hospitalization) in some veterinary patients and increased management of geriatric veterinary patients with multiple comorbidities. Advancements in the management of AKI, including the increased availability of renal replacement therapies, have been made; however, the overall mortality of animals with AKI remains high. Despite the high prevalence of AKI and the high mortality rate, the body of evidence regarding the diagnosis and the management of AKI in veterinary medicine is very limited. Consequently, the International Renal Interest Society (IRIS) constructed a working group to provide guidelines for animals with AKI. Recommendations are based on the available literature and the clinical experience of the members of the working group and reflect consensus of opinion. Fifty statements were generated and were voted on in all aspects of AKI and explanatory text can be found either before or after each statement.
摘要：
急性肾损伤（AKI）定义为肾实质损伤，有或没有肾功能下降，如尿毒症毒素的积累或尿液产生的改变所反映的(即，增加或减少)。AKI可能是由几个因素中的任何一个引起的，包括缺血,炎症,肾毒素，和传染病。AKI可以是社区或医院获得的。后者以前不被认为是动物AKI的常见原因；然而，最近的证据表明,兽医学中医院获得性AKI的患病率正在增加.这可能是由于对AKI的认识和认识增加，以及增加的治疗强度(例如，通气和长期住院）在一些兽医患者中，并增加了对患有多种合并症的老年兽医患者的管理。AKI管理的进步，包括肾脏替代疗法的增加，已经制造了；然而，动物中AKI的总死亡率仍然很高.尽管AKI患病率高，死亡率高，关于兽医学中AKI的诊断和管理的证据非常有限.因此,国际肾脏权益协会(IRIS)成立了一个工作组,为患有AKI的动物提供指南.建议基于现有文献和工作组成员的临床经验，并反映了共识。在AKI的所有方面产生了50份声明并进行了表决，解释性文本可以在每次声明之前或之后找到。
