Abstract：
OBJECTIVE: Patients with focal drug resistant epilepsy are excellent candidates for epilepsy surgery. Status epilepticus (SE) and seizure clusters (SC), described in a subset of patients, have both been associated with extended epileptogenic cerebral networks within one or both hemispheres. In this retrospective study, we were interested to determine if a history of SE or SC is associated with a worse surgical outcome.
METHODS: Data of 244 patients operated between 2000 to 2018 were reviewed, with a follow-up of at least 2 years. Patients with a previous history of SE or SC were compared to operated patients without these conditions (control group, CG).
RESULTS: We identified 27 (11%) and 38 (15.5%) patients with history of SE or SC, respectively. No difference in post-operative outcome was found for SE and SC patients. Compared to the control group, patients with a history of SE were diagnosed and operated significantly at earlier age(p = 0.01), and after a shorter duration of the disease (p = 0.027), but with a similar age of onset.
CONCLUSIONS: A history of SE or SC was not associated with a worse post-operative prognosis. Earlier referral of SE patients for surgery suggests a heightened awareness regarding serious complications of recurrent SE by the referring neurologist or neuropediatrician. While the danger of SE is evident, policies to underline the impact for SC or very frequent seizures might be an efficient approach to accelerate patient referral also for this patient group.
METHODS: Data of 244 patients operated between 2000 to 2018 were reviewed, with a follow-up of at least 2 years. Patients with a previous history of SE or SC were compared to operated patients without these conditions (control group, CG).
RESULTS: We identified 27 (11%) and 38 (15.5%) patients with history of SE or SC, respectively. No difference in post-operative outcome was found for SE and SC patients. Compared to the control group, patients with a history of SE were diagnosed and operated significantly at earlier age(p = 0.01), and after a shorter duration of the disease (p = 0.027), but with a similar age of onset.
CONCLUSIONS: A history of SE or SC was not associated with a worse post-operative prognosis. Earlier referral of SE patients for surgery suggests a heightened awareness regarding serious complications of recurrent SE by the referring neurologist or neuropediatrician. While the danger of SE is evident, policies to underline the impact for SC or very frequent seizures might be an efficient approach to accelerate patient referral also for this patient group.
摘要：
目的：局灶性耐药癫痫患者是癫痫手术的理想选择。癫痫持续状态（SE）和癫痫发作簇（SC），在一部分患者中描述，两者都与一个或两个半球内扩展的癫痫性大脑网络有关。在这项回顾性研究中,我们有兴趣确定SE或SC病史是否与较差的手术结果相关.
方法：回顾了2000年至2018年间244例手术患者的数据，至少随访2年。将既往有SE或SC病史的患者与没有这些疾病的手术患者进行比较（对照组，CG）。
结果：我们确定了27例（11％）和38例（15.5％）具有SE或SC病史的患者，分别。SE和SC患者的术后结局没有差异。与对照组相比,有SE病史的患者在较早的年龄诊断和手术显著(p=0.01)，在疾病持续时间较短(p=0.027)后，但是发病年龄相似。
结论：SE或SC病史与术后不良预后无关。早期转诊的SE患者进行手术表明，转诊的神经科医生或神经儿科医生对复发性SE的严重并发症的认识有所提高。虽然SE的危险是显而易见的，强调对SC或非常频繁的癫痫发作的影响的政策可能是加速该患者组患者转诊的有效方法.
方法：回顾了2000年至2018年间244例手术患者的数据，至少随访2年。将既往有SE或SC病史的患者与没有这些疾病的手术患者进行比较（对照组，CG）。
结果：我们确定了27例（11％）和38例（15.5％）具有SE或SC病史的患者，分别。SE和SC患者的术后结局没有差异。与对照组相比,有SE病史的患者在较早的年龄诊断和手术显著(p=0.01)，在疾病持续时间较短(p=0.027)后，但是发病年龄相似。
结论：SE或SC病史与术后不良预后无关。早期转诊的SE患者进行手术表明，转诊的神经科医生或神经儿科医生对复发性SE的严重并发症的认识有所提高。虽然SE的危险是显而易见的，强调对SC或非常频繁的癫痫发作的影响的政策可能是加速该患者组患者转诊的有效方法.
