PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to histologically compare the status of Schlemm\'s canal (SC) and Schlemm\'s canal endothelial (SCE) cells between trabeculectomy specimens from patients with primary open-angle glaucoma (POAG) and exfoliation glaucoma (EXG).
UNASSIGNED: A total of 182 eyes from 152 patients with POAG and 138 eyes from 116 patients with EXG underwent immunohistochemical staining for thrombomodulin. Equal numbers of cases were selected from both groups using propensity score matching. The following parameters were evaluated: total SC length, staining positive and negative SC length (PSC and NSC, respectively), opened and closed SC length, staining positive and opened SC length, staining positive and closed SC length, staining negative and opened SC length (NOSC), and staining negative and closed SC length.
UNASSIGNED: After matching for age and gender, 87 cases were selected in each group. The EXG group had significantly higher preoperative IOP and medication scores. PSC was significantly longer in the POAG group, while NSC and NOSC were longer in the EXG group. Multiple regression analysis of these 174 cases revealed that PSC was significantly shorter in the EXG group. After matching for age, gender, preoperative IOP, and medication score, 64 cases were selected in each group, and NOSC was significantly longer in the EXG group.
UNASSIGNED: These findings suggest that in EXG, SCE loss occurs independently of background factors such as aging and medication use. The loss of SCE may have a more critical impact on IOP elevation in EXG compared to POAG.
UNASSIGNED: A total of 182 eyes from 152 patients with POAG and 138 eyes from 116 patients with EXG underwent immunohistochemical staining for thrombomodulin. Equal numbers of cases were selected from both groups using propensity score matching. The following parameters were evaluated: total SC length, staining positive and negative SC length (PSC and NSC, respectively), opened and closed SC length, staining positive and opened SC length, staining positive and closed SC length, staining negative and opened SC length (NOSC), and staining negative and closed SC length.
UNASSIGNED: After matching for age and gender, 87 cases were selected in each group. The EXG group had significantly higher preoperative IOP and medication scores. PSC was significantly longer in the POAG group, while NSC and NOSC were longer in the EXG group. Multiple regression analysis of these 174 cases revealed that PSC was significantly shorter in the EXG group. After matching for age, gender, preoperative IOP, and medication score, 64 cases were selected in each group, and NOSC was significantly longer in the EXG group.
UNASSIGNED: These findings suggest that in EXG, SCE loss occurs independently of background factors such as aging and medication use. The loss of SCE may have a more critical impact on IOP elevation in EXG compared to POAG.
摘要：
■本研究旨在从组织学上比较原发性开角型青光眼（POAG）和剥脱性青光眼（EXG）患者的小梁切除术标本之间Schlemm管（SC）和Schlemm管内皮（SCE）细胞的状态。
■152例POAG患者的182只眼和116例EXG患者的138只眼接受了血栓调节蛋白的免疫组织化学染色。使用倾向评分匹配从两组中选择相同数量的病例。评估了以下参数：总SC长度，染色阳性和阴性SC长度(PSC和NSC，分别)，打开和关闭SC长度，染色阳性和开放SC长度，染色阳性和闭合SC长度，染色阴性和开放SC长度（NOSC），和染色阴性和闭合SC长度。
■匹配年龄和性别后，每组87例。EXG组术前IOP和用药评分明显高于对照组。POAG组的PSC明显延长，而EXG组NSC和NOSC时间较长。对这174例患者的多元回归分析显示，EXG组的PSC明显较短。年龄匹配后，性别,术前IOP,和药物评分，每组64例,EXG组的NOSC明显延长。
■这些发现表明，在EXG中，SCE损失的发生与背景因素无关，例如衰老和药物使用。与POAG相比，SCE的损失可能对EXG中的IOP升高具有更关键的影响。
■152例POAG患者的182只眼和116例EXG患者的138只眼接受了血栓调节蛋白的免疫组织化学染色。使用倾向评分匹配从两组中选择相同数量的病例。评估了以下参数：总SC长度，染色阳性和阴性SC长度(PSC和NSC，分别)，打开和关闭SC长度，染色阳性和开放SC长度，染色阳性和闭合SC长度，染色阴性和开放SC长度（NOSC），和染色阴性和闭合SC长度。
■匹配年龄和性别后，每组87例。EXG组术前IOP和用药评分明显高于对照组。POAG组的PSC明显延长，而EXG组NSC和NOSC时间较长。对这174例患者的多元回归分析显示，EXG组的PSC明显较短。年龄匹配后，性别,术前IOP,和药物评分，每组64例,EXG组的NOSC明显延长。
■这些发现表明，在EXG中，SCE损失的发生与背景因素无关，例如衰老和药物使用。与POAG相比，SCE的损失可能对EXG中的IOP升高具有更关键的影响。
