PDF(Pubmed)
Abstract：
Myocardial ischemia may induce myocardial fibrosis, a condition that progressively leads to ventricular remodeling, heightening the risk of heart failure. The timely detection of myocardial fibrosis is crucial for intervention and improved outcomes. 68Ga-FAPI-04 PET/CT shows promise in assessing fibroblast activation in patients with early myocardial infarction characterized by prolonged myocardial ischemia. However, there is a notable absence of data regarding patients with short-term myocardial ischemia, such as those experiencing unstable angina (UA). In this report, we evaluated a 49-year-old male with UA and severe stenosis in multiple coronary arteries using 68Ga-FAPI-04 PET/CT. The results demonstrated tracer-specific uptake (SUVmax = 4.6) in the left anterior descending artery (LAD) territory, consistent with myocardial anterior wall ischemia indicated by the electrocardiogram. Following vascular recanalization therapy and regular medication treatment, the patient remained free of angina recurrence. A subsequent review at 2 months revealed a significant reduction in myocardial tracer uptake (SUVmax = 1.8). This case illustrates the validity of 68Ga-FAPI-04 PET/CT in assessing the extent of early myocardial fibroblast activation in patients with UA. This approach offers valuable insights for early detection and visual evidence, providing information on disease progression and treatment response.
摘要：
心肌缺血可诱发心肌纤维化,一种逐渐导致心室重塑的情况，增加心力衰竭的风险。及时检测心肌纤维化对于干预和改善预后至关重要。68Ga-FAPI-04PET/CT在评估以长期心肌缺血为特征的早期心肌梗死患者的成纤维细胞活化方面显示出希望。然而,关于短期心肌缺血患者的数据明显缺乏，例如经历不稳定型心绞痛(UA)的患者。在这份报告中,我们使用68Ga-FAPI-04PET/CT评估了一名49岁的UA和多冠状动脉严重狭窄的男性。结果表明，左前降支（LAD）区域存在示踪剂特异性摄取（SUVmax=4.6），符合心电图显示的心肌前壁缺血。在血管再通治疗和常规药物治疗后，患者没有心绞痛复发.随后在2个月时进行的审查显示，心肌示踪剂摄取显着减少（SUVmax=1.8）。该病例说明了68Ga-FAPI-04PET/CT在评估UA患者早期心肌成纤维细胞活化程度方面的有效性。这种方法为早期发现和视觉证据提供了有价值的见解，提供有关疾病进展和治疗反应的信息。
