PDF(Pubmed)
Abstract：
Pilocytic astrocytoma (PA), recognized as the most prevalent central nervous system (CNS) tumor, has long been associated with calcifications, a characteristic often attributed to benign or indolent growth patterns. In this study, we explored the calcified attributes in these tumors that beckon a deeper understanding. This is a retrospective study, on a set of seven cases, with a histopathological diagnosis of pilocytic astrocytoma with calcifications and psammoma bodies (PB). Despite an encouraging overall survival outcome, the recurrence in four cases cast some doubt on the conventional classification. The histological study of these cases revealed a spectrum of calcifications, varying in size and morphology, all of which exhibited positive reactivity to glial fibrillary acidic protein (GFAP), osteoconduction, and osteopontin. Notably, the immunohistochemistry showed hyaline bodies displaying an atypical immune profile, strikingly negative for vimentin and GFAP, and a robust positivity for epidermal growth factor receptors (EGFR), tumor necrosis factor-alpha (TNF-α), and interleukin 1 beta (IL-1β). These results stimulated speculation that the identity of these calcified tumors may have extended and potentially embraced the realm of calcifying pseudoneoplasms of the neuraxis (CAPNON), underscored by intense pilot gliosis. This study transcends mere anatomical exploration; it delves into the intricacies of calcified tumors, casting a spotlight on the dynamic interplay between PA and CAPNON. As we traverse the frontiers of neuro-oncology, these findings pave the way for innovative avenues in the diagnostics and therapeutics of these tumors.
摘要：
毛细胞星形细胞瘤(PA),公认为最常见的中枢神经系统（CNS）肿瘤，长期以来一直与钙化有关，一种通常归因于良性或惰性生长模式的特征。在这项研究中,我们探索了这些肿瘤的钙化属性，这吸引了更深入的理解。这是一项回顾性研究,在一组七个案例中，具有组织病理学诊断的毛细胞星形细胞瘤伴钙化和砂膜体（PB）。尽管总体生存结果令人鼓舞，四例病例的复发使人们对传统分类产生了怀疑。这些病例的组织学研究显示了一系列钙化，大小和形态不同，所有这些都对胶质纤维酸性蛋白（GFAP）表现出阳性反应，骨传导,和骨桥蛋白.值得注意的是,免疫组织化学显示透明体显示出非典型的免疫特征，波形蛋白和GFAP呈显著阴性，和表皮生长因子受体（EGFR）的强阳性，肿瘤坏死因子-α（TNF-α），和白细胞介素1β（IL-1β）。这些结果激发了人们的猜测，即这些钙化肿瘤的身份可能已经扩展并可能涵盖了神经轴钙化假性肿瘤（CAPNON）的领域，飞行员强烈的胶质增生强调了这一点。这项研究超越了单纯的解剖学探索；它深入研究了钙化肿瘤的复杂性，聚焦于PA和CAPNON之间的动态相互作用。当我们穿越神经肿瘤学的前沿时，这些发现为这些肿瘤的诊断和治疗的创新途径铺平了道路。
