PDF(Pubmed)
Abstract：
The objective of this systematic review was to assess the effectiveness, acceptability, and safety of systemic enzyme therapy, consisting of trypsin, bromelain, and rutoside trihydrate, as an anti-inflammatory agent, either when utilized independently or in conjunction with non-steroidal anti-inflammatory drugs (NSAIDs). This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two studies met the inclusion criteria and were assessed in the review. The bias risk was evaluated using the risk-of-bias tool for randomized trials (RoB 2). Both studies revealed highly significant results for the study population. Individuals receiving oral enzymes and diclofenac sodium combination therapy showed a significant improvement in pain reduction, better eating, and mouth opening, as well as a decrease in joint noise and jerky mandibular motions. Patients receiving systemic enzyme therapy with diclofenac combinations performed better than those receiving NSAIDs alone, and the differences were quite substantial. For the treatment of internal derangement of the temporomandibular joint (TMJ), we recommend combining enzymes and diclofenac. Systemic enzyme therapy can be used in the treatment of TMJ osteoarthritis, as it shows a highly significant result in the study population.
摘要：
这次系统审查的目的是评估有效性，可接受性,和系统酶疗法的安全性，由胰蛋白酶组成，菠萝蛋白酶,和Rutoside三水合物，作为抗炎药，独立使用或与非甾体抗炎药（NSAIDs）联合使用。本系统评价遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目。两项研究符合纳入标准，并在审查中进行了评估。使用随机试验的偏倚风险工具(RoB2)评估偏倚风险。两项研究都显示了对研究人群非常重要的结果。接受口服酶和双氯芬酸钠联合治疗的个体在减轻疼痛方面显着改善，更好的吃,张开嘴，以及关节噪音和下颌运动的减少。接受双氯芬酸联合全身酶治疗的患者比单独接受NSAIDs的患者表现更好。差异相当大。用于治疗颞下颌关节（TMJ）内部紊乱，我们建议结合酶和双氯芬酸。系统性酶疗法可用于治疗TMJ骨关节炎，因为它在研究人群中显示出非常重要的结果。
