Abstract：
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap \'n\' Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, and oxidative stress. Additionally, it is involved in immune system development. More importantly, BACH1 is highly expressed in and plays a key role in numerous malignant tumors, affecting cellular metabolism, tumor invasion and metastasis, proliferation, different cell death pathways, drug resistance, and the tumor microenvironment. However, few articles systematically summarized the roles of BACH1 in cancer. This review aims to highlight the research status of BACH1 in malignant tumor behaviors, and summarize its role in immune regulation in cancer. Moreover, this review focuses on the potential of BACH1 as a novel therapeutic target and prognostic biomarker. Notably, the mechanisms underlying the roles of BACH1 in ferroptosis, oxidative stress and tumor microenvironment remain to be explored. BACH1 has a dual impact on cancer, which affects the accuracy and efficiency of targeted drug delivery. Finally, the promising directions of future BACH1 research are prospected. A systematical and clear understanding of BACH1 would undoubtedly take us one step closer to facilitating its translation from basic research into the clinic.
摘要：
转录因子BTB结构域和CNC同源物1（BACH1）属于Cap\'n\'衣领和碱性区亮氨酸拉链（CNC-bZIP）家族。BACH1在哺乳动物组织中广泛表达，它调节表观遗传修饰，血红素稳态,和氧化应激。此外,它参与免疫系统的发育。更重要的是,BACH1在许多恶性肿瘤中高表达并发挥关键作用，影响细胞代谢，肿瘤侵袭和转移，扩散,不同的细胞死亡途径，耐药性,和肿瘤微环境。然而,很少有文章系统地总结了BACH1在癌症中的作用。本综述旨在强调BACH1在恶性肿瘤行为中的研究现状。并总结其在肿瘤免疫调节中的作用。此外，本文就BACH1作为新的治疗靶点和预后生物标志物的潜力进行综述.值得注意的是,BACH1在铁凋亡中的作用机制，氧化应激和肿瘤微环境仍有待探索。BACH1对癌症有双重影响，影响靶向给药的准确性和效率。最后,展望了未来BACH1研究的有希望的方向。对BACH1的系统和清晰的理解无疑将使我们更接近于促进其从基础研究到临床的转化。
