Abstract：
BACKGROUND: To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV).
METHODS: A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The neovascular signal relationship between PSV and mCNV were classified into the presence of neovascular signal of CNV around PSV or not. The recurrence of mCNV, best-corrected visual acuity (BCVA), hyperreflective foci height, CNV area and CNV flow area were analyzed between two groups.
RESULTS: Neovascular signal of CNV around PSV was detected in 20 eyes (39.2%). The one-year recurrence rate in the group with neovascular signal of CNV around PSV was significantly higher than that in the group without neovascular signal of CNV around PSV (P = 0.045). The recurrence time in the group with neovascular signal around PSV was shorter than that in the group without neovascular signal around PSV (P = 0.030). Cox proportional hazard model showed that the presence of neovascular signal of CNV around PSV [hazard ratio (HR): 2.904] and subfoveal choroidal thickness ≤ 50 μm (HR: 0.368) were risk factors for recurrence of mCNV. In the group with neovascular signal around PSV, the BCVA was worse (P = 0.024) and the CNV flow area was more unstable (P = 0.027) after therapy.
CONCLUSIONS: PSV was commonly detected in patients with mCNV. The presence of neovascular signal of CNV around PSV was prone to recur with a shorter time in mCNV patients.
METHODS: A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The neovascular signal relationship between PSV and mCNV were classified into the presence of neovascular signal of CNV around PSV or not. The recurrence of mCNV, best-corrected visual acuity (BCVA), hyperreflective foci height, CNV area and CNV flow area were analyzed between two groups.
RESULTS: Neovascular signal of CNV around PSV was detected in 20 eyes (39.2%). The one-year recurrence rate in the group with neovascular signal of CNV around PSV was significantly higher than that in the group without neovascular signal of CNV around PSV (P = 0.045). The recurrence time in the group with neovascular signal around PSV was shorter than that in the group without neovascular signal around PSV (P = 0.030). Cox proportional hazard model showed that the presence of neovascular signal of CNV around PSV [hazard ratio (HR): 2.904] and subfoveal choroidal thickness ≤ 50 μm (HR: 0.368) were risk factors for recurrence of mCNV. In the group with neovascular signal around PSV, the BCVA was worse (P = 0.024) and the CNV flow area was more unstable (P = 0.027) after therapy.
CONCLUSIONS: PSV was commonly detected in patients with mCNV. The presence of neovascular signal of CNV around PSV was prone to recur with a shorter time in mCNV patients.
摘要：
背景：根据穿孔巩膜血管（PSV）周围mCNV的新生血管信号，比较近视脉络膜新生血管（mCNV）的复发。
方法：连续一系列初治mCNV患者接受抗VEGF治疗，随访时间至少为12个月。PSV和mCNV之间的新生血管信号关系分为PSV周围是否存在CNV的新生血管信号。mCNV复发,最佳矫正视力（BCVA），超反射焦点高度，分析两组之间的CNV面积和CNV流量面积。
结果：在20只眼（39.2％）中检测到PSV周围CNV的新生血管信号。PSV周围有CNV新生血管信号组1年复发率明显高于PSV周围无CNV新生血管信号组(P=0.045)。PSV周围有新生血管信号组的复发时间短于PSV周围无新生血管信号组(P=0.030)。Cox比例风险模型显示，在PSV周围存在CNV新生血管信号[风险比（HR）：2.904]和中央凹下脉络膜厚度≤50μm（HR：0.368）是mCNV复发的危险因素。在PSV周围有新生血管信号的组中，治疗后BCVA更差（P=0.024），CNV流量面积更不稳定（P=0.027）。
结论：PSV通常在mCNV患者中检测到。在mCNV患者中，PSV周围CNV的新生血管信号的存在容易以较短的时间复发。
方法：连续一系列初治mCNV患者接受抗VEGF治疗，随访时间至少为12个月。PSV和mCNV之间的新生血管信号关系分为PSV周围是否存在CNV的新生血管信号。mCNV复发,最佳矫正视力（BCVA），超反射焦点高度，分析两组之间的CNV面积和CNV流量面积。
结果：在20只眼（39.2％）中检测到PSV周围CNV的新生血管信号。PSV周围有CNV新生血管信号组1年复发率明显高于PSV周围无CNV新生血管信号组(P=0.045)。PSV周围有新生血管信号组的复发时间短于PSV周围无新生血管信号组(P=0.030)。Cox比例风险模型显示，在PSV周围存在CNV新生血管信号[风险比（HR）：2.904]和中央凹下脉络膜厚度≤50μm（HR：0.368）是mCNV复发的危险因素。在PSV周围有新生血管信号的组中，治疗后BCVA更差（P=0.024），CNV流量面积更不稳定（P=0.027）。
结论：PSV通常在mCNV患者中检测到。在mCNV患者中，PSV周围CNV的新生血管信号的存在容易以较短的时间复发。
