Abstract：
OBJECTIVE: To compare the effectiveness and safety of pharmacological thrombolysis and mechanical thrombectomy.
METHODS: This review was conducted in accordance with the PRISMA guidelines. Pooled proportions and subgroup analysis were calculated for primary and secondary patency rates, technical success, clinical success, major and minor complications rates.
RESULTS: This systematic review identified a total of 6,492 studies of which 17 studies were included for analysis. A total of 1,089 patients comprising 451 (41.4 %) and 638 (58.6 %) patients who underwent thrombolysis and mechanical thrombectomy procedures, respectively, were analysed. No significant differences were observed between thrombolysis and mechanical thrombectomy procedures in terms of technical success, clinical success, major and minor complications rates, primary and secondary patency rates; however, subgroup analysis of overall arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) demonstrated a significantly higher rate of major complications within the AVF group (p=0.0248).
CONCLUSIONS: The present meta-analysis suggests that pharmacological thrombolysis and mechanical thrombectomy procedures are similarly effective and safe; however, AVFs are subject to higher major complications compared to AVGs.
METHODS: This review was conducted in accordance with the PRISMA guidelines. Pooled proportions and subgroup analysis were calculated for primary and secondary patency rates, technical success, clinical success, major and minor complications rates.
RESULTS: This systematic review identified a total of 6,492 studies of which 17 studies were included for analysis. A total of 1,089 patients comprising 451 (41.4 %) and 638 (58.6 %) patients who underwent thrombolysis and mechanical thrombectomy procedures, respectively, were analysed. No significant differences were observed between thrombolysis and mechanical thrombectomy procedures in terms of technical success, clinical success, major and minor complications rates, primary and secondary patency rates; however, subgroup analysis of overall arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) demonstrated a significantly higher rate of major complications within the AVF group (p=0.0248).
CONCLUSIONS: The present meta-analysis suggests that pharmacological thrombolysis and mechanical thrombectomy procedures are similarly effective and safe; however, AVFs are subject to higher major complications compared to AVGs.
摘要：
目的：比较药物溶栓和机械取栓的有效性和安全性。
方法：本综述按照PRISMA指南进行。合并比例和亚组分析计算主要和次要通畅率，技术上的成功,临床成功，主要和次要并发症发生率。
结果：本系统评价共确定了6,492项研究，其中17项研究纳入分析。共有1,089名患者，包括451名（41.4%）和638名（58.6%）接受过溶栓和机械取栓手术的患者，分别,进行了分析。在技术成功方面，溶栓和机械取栓之间没有观察到显着差异。临床成功，主要和次要并发症发生率，初级和次级通畅率；然而，对整体动静脉瘘(AVFs)和动静脉移植物(AVGs)的亚组分析显示,AVF组中主要并发症的发生率明显较高(p=0.0248).
结论：目前的荟萃分析表明，药物溶栓和机械取栓手术同样有效和安全；然而，与AVG相比,AVF经受更高的主要并发症。
方法：本综述按照PRISMA指南进行。合并比例和亚组分析计算主要和次要通畅率，技术上的成功,临床成功，主要和次要并发症发生率。
结果：本系统评价共确定了6,492项研究，其中17项研究纳入分析。共有1,089名患者，包括451名（41.4%）和638名（58.6%）接受过溶栓和机械取栓手术的患者，分别,进行了分析。在技术成功方面，溶栓和机械取栓之间没有观察到显着差异。临床成功，主要和次要并发症发生率，初级和次级通畅率；然而，对整体动静脉瘘(AVFs)和动静脉移植物(AVGs)的亚组分析显示,AVF组中主要并发症的发生率明显较高(p=0.0248).
结论：目前的荟萃分析表明，药物溶栓和机械取栓手术同样有效和安全；然而，与AVG相比,AVF经受更高的主要并发症。
