Abstract：
BACKGROUND: The duration and potency of the subarachnoid block (SAB) can be enhanced by incorporating spinal additives into local anesthetics. In this study, the effectiveness of intrathecal fentanyl and magnesium sulphate as adjuvant anesthetics to 0.5% hyperbaric bupivacaine is compared in regard to the onset and duration of sensory and motor block, along with circulatory variables.
METHODS: After authorization of ethical committee , 100 patients belonging to American Society of Anesthesiologists grades I and II, were chosen and split into two groups with 50 patients each. A SAB was administered; Group 1 was given 2.5 mL of 0.5% hyperbaric bupivacaine + 0.5 mL of fentanyl (25 μg), and Group 2 received 2.5 mL of 0.5% hyperbaric bupivacaine + 0.2 mL of magnesium sulphate (100 mg). 0.3 mL of distilled water was added to both groups making an intrathecal drug volume of 3.0 mL. Perioperative circulatory parameters and sensory and motor block features are noted and compared. Version 21.0 of Statistical Package for the Social for Windows was used for all statistical calculations.
RESULTS: Group 1 had a faster onset of sensory and motor block in comparison to Group 2. However, both groups were statistically similar with regard to the duration of sensory and motor blockade, visual analog scale scores, intra and postoperative hemodynamic parameters.
CONCLUSIONS: 0.5 mL fentanyl functions as a better spinal adjuvant to 0.5% hyperbaric bupivacaine compared to magnesium sulphate, block but both the agents had similar duration of block, postoperative analgesia and hemodynamic parameters.
METHODS: After authorization of ethical committee , 100 patients belonging to American Society of Anesthesiologists grades I and II, were chosen and split into two groups with 50 patients each. A SAB was administered; Group 1 was given 2.5 mL of 0.5% hyperbaric bupivacaine + 0.5 mL of fentanyl (25 μg), and Group 2 received 2.5 mL of 0.5% hyperbaric bupivacaine + 0.2 mL of magnesium sulphate (100 mg). 0.3 mL of distilled water was added to both groups making an intrathecal drug volume of 3.0 mL. Perioperative circulatory parameters and sensory and motor block features are noted and compared. Version 21.0 of Statistical Package for the Social for Windows was used for all statistical calculations.
RESULTS: Group 1 had a faster onset of sensory and motor block in comparison to Group 2. However, both groups were statistically similar with regard to the duration of sensory and motor blockade, visual analog scale scores, intra and postoperative hemodynamic parameters.
CONCLUSIONS: 0.5 mL fentanyl functions as a better spinal adjuvant to 0.5% hyperbaric bupivacaine compared to magnesium sulphate, block but both the agents had similar duration of block, postoperative analgesia and hemodynamic parameters.
摘要：
背景：可以通过将脊髓添加剂掺入局部麻醉剂来增强蛛网膜下腔阻滞（SAB）的持续时间和效力。在这项研究中,鞘内注射芬太尼和硫酸镁作为辅助麻醉药对0.5％高压布比卡因的有效性比较了感觉和运动阻滞的发作和持续时间，以及循环变量。
方法：经伦理委员会授权，100名患者属于美国麻醉医师协会一级和二级，选择并分为两组，每组50例患者。给予SAB；第1组给予2.5mL0.5％高压布比卡因+0.5mL芬太尼（25μg），第2组接受2.5mL0.5%高压布比卡因+0.2mL硫酸镁(100mg).向两组中加入0.3mL蒸馏水,使鞘内药物体积为3.0mL。注意并比较围手术期循环参数以及感觉和运动阻滞特征。SocialforWindows统计软件包的21.0版用于所有统计计算。
结果：与第2组相比，第1组的感觉和运动阻滞发作更快。然而,两组的感觉和运动阻滞持续时间在统计学上相似，视觉模拟量表评分，术中和术后血流动力学参数。
结论：与硫酸镁相比，0.5mL芬太尼作为0.5%高压布比卡因更好的脊髓佐剂，阻断，但两种药物的阻断持续时间相似，术后镇痛和血流动力学参数。
方法：经伦理委员会授权，100名患者属于美国麻醉医师协会一级和二级，选择并分为两组，每组50例患者。给予SAB；第1组给予2.5mL0.5％高压布比卡因+0.5mL芬太尼（25μg），第2组接受2.5mL0.5%高压布比卡因+0.2mL硫酸镁(100mg).向两组中加入0.3mL蒸馏水,使鞘内药物体积为3.0mL。注意并比较围手术期循环参数以及感觉和运动阻滞特征。SocialforWindows统计软件包的21.0版用于所有统计计算。
结果：与第2组相比，第1组的感觉和运动阻滞发作更快。然而,两组的感觉和运动阻滞持续时间在统计学上相似，视觉模拟量表评分，术中和术后血流动力学参数。
结论：与硫酸镁相比，0.5mL芬太尼作为0.5%高压布比卡因更好的脊髓佐剂，阻断，但两种药物的阻断持续时间相似，术后镇痛和血流动力学参数。
