Abstract：
OBJECTIVE: Lacrimal gland enlargement is a common feature of thyroid eye disease (TED) and has been positively correlated with the clinical activity score. Although lacrimal gland volume is the preferred measure of lacrimal gland size, its calculation is not clinically translatable due to the expertise, time and advanced software required. The aim of our study is to determine whether the lacrimal gland volume in patients with TED undergoing magnetic resonance imaging (MRI) can be estimated using simpler lacrimal gland linear and area measurements.
METHODS: A retrospective review of 102 orbits (51 patients) with TED who underwent orbital MRI was conducted. The maximum length, width, and area of the lacrimal gland were measured in axial and coronal sections. Lacrimal gland volume was calculated by using a manual segmentation technique on all consecutive axial slices on commercially available software, OsiriX. All quantitative measurements were correlated with the lacrimal gland volume.
RESULTS: Mean age of participants was 59 ± 16 years, and 67% (n = 34) were females. With multivariate analyses, combined lacrimal gland axial and coronal areas strongly correlated with volume (r = 0.843, p < 0.01). Strong univariate predictors of volume included axial area (r = 0.704, p < 0.01) and coronal area (r = 0.722, p < 0.01), while moderate predictors included axial length (r = 0.523, p < 0.01), axial width (r = 0.521, p < 0.01), coronal length (r = 0.450, p < 0.01), and coronal width (r = 0.649, p < 0.01).
CONCLUSIONS: In patients with thyroid eye disease, lacrimal gland volume can be estimated using axial and coronal areas, which is simpler and more time efficient than calculating volumes.
METHODS: A retrospective review of 102 orbits (51 patients) with TED who underwent orbital MRI was conducted. The maximum length, width, and area of the lacrimal gland were measured in axial and coronal sections. Lacrimal gland volume was calculated by using a manual segmentation technique on all consecutive axial slices on commercially available software, OsiriX. All quantitative measurements were correlated with the lacrimal gland volume.
RESULTS: Mean age of participants was 59 ± 16 years, and 67% (n = 34) were females. With multivariate analyses, combined lacrimal gland axial and coronal areas strongly correlated with volume (r = 0.843, p < 0.01). Strong univariate predictors of volume included axial area (r = 0.704, p < 0.01) and coronal area (r = 0.722, p < 0.01), while moderate predictors included axial length (r = 0.523, p < 0.01), axial width (r = 0.521, p < 0.01), coronal length (r = 0.450, p < 0.01), and coronal width (r = 0.649, p < 0.01).
CONCLUSIONS: In patients with thyroid eye disease, lacrimal gland volume can be estimated using axial and coronal areas, which is simpler and more time efficient than calculating volumes.
摘要：
目的：泪腺肿大是甲状腺眼病（TED）的常见特征，与临床活动评分呈正相关。尽管泪腺体积是测量泪腺大小的首选方法，由于专业知识，它的计算在临床上是不可翻译的，需要时间和先进的软件。我们研究的目的是确定是否可以使用更简单的泪腺线性和面积测量来估计接受磁共振成像（MRI）的TED患者的泪腺体积。
方法：对102例（51例）TED患者进行眼眶MRI的回顾性分析。最大长度,宽度,在轴向和冠状部分测量泪腺面积。通过在市售软件上对所有连续的轴向切片使用手动分割技术计算泪腺体积，Osirix.所有定量测量均与泪腺体积相关。
结果：参与者的平均年龄为59±16岁，67%(n=34)为女性。通过多变量分析，合并泪腺轴位和冠状面积与体积密切相关（r=0.843，p<0.01）。强单变量体积预测因子包括轴向面积（r=0.704，p<0.01）和冠状面积（r=0.722，p<0.01），而中等预测因子包括轴向长度(r=0.523，p<0.01)，轴向宽度（r=0.521，p<0.01），冠状长度（r=0.450，p<0.01），冠状宽度(r=0.649,p<0.01)。
结论：甲状腺眼病患者，可以使用轴向和冠状区域来估计泪腺体积，这比计算体积更简单，更省时。
方法：对102例（51例）TED患者进行眼眶MRI的回顾性分析。最大长度,宽度,在轴向和冠状部分测量泪腺面积。通过在市售软件上对所有连续的轴向切片使用手动分割技术计算泪腺体积，Osirix.所有定量测量均与泪腺体积相关。
结果：参与者的平均年龄为59±16岁，67%(n=34)为女性。通过多变量分析，合并泪腺轴位和冠状面积与体积密切相关（r=0.843，p<0.01）。强单变量体积预测因子包括轴向面积（r=0.704，p<0.01）和冠状面积（r=0.722，p<0.01），而中等预测因子包括轴向长度(r=0.523，p<0.01)，轴向宽度（r=0.521，p<0.01），冠状长度（r=0.450，p<0.01），冠状宽度(r=0.649,p<0.01)。
结论：甲状腺眼病患者，可以使用轴向和冠状区域来估计泪腺体积，这比计算体积更简单，更省时。
