METHODS: A retrospective review of 102 orbits (51 patients) with TED who underwent orbital MRI was conducted. The maximum length, width, and area of the lacrimal gland were measured in axial and coronal sections. Lacrimal gland volume was calculated by using a manual segmentation technique on all consecutive axial slices on commercially available software, OsiriX. All quantitative measurements were correlated with the lacrimal gland volume.
RESULTS: Mean age of participants was 59 ± 16 years, and 67% (n = 34) were females. With multivariate analyses, combined lacrimal gland axial and coronal areas strongly correlated with volume (r = 0.843, p < 0.01). Strong univariate predictors of volume included axial area (r = 0.704, p < 0.01) and coronal area (r = 0.722, p < 0.01), while moderate predictors included axial length (r = 0.523, p < 0.01), axial width (r = 0.521, p < 0.01), coronal length (r = 0.450, p < 0.01), and coronal width (r = 0.649, p < 0.01).
CONCLUSIONS: In patients with thyroid eye disease, lacrimal gland volume can be estimated using axial and coronal areas, which is simpler and more time efficient than calculating volumes.
方法:对102例(51例)TED患者进行眼眶MRI的回顾性分析。最大长度,宽度,在轴向和冠状部分测量泪腺面积。通过在市售软件上对所有连续的轴向切片使用手动分割技术计算泪腺体积,Osirix.所有定量测量均与泪腺体积相关。
结果:参与者的平均年龄为59±16岁,67%(n=34)为女性。通过多变量分析,合并泪腺轴位和冠状面积与体积密切相关(r=0.843,p<0.01)。强单变量体积预测因子包括轴向面积(r=0.704,p<0.01)和冠状面积(r=0.722,p<0.01),而中等预测因子包括轴向长度(r=0.523,p<0.01),轴向宽度(r=0.521,p<0.01),冠状长度(r=0.450,p<0.01),冠状宽度(r=0.649,p<0.01)。
结论:甲状腺眼病患者,可以使用轴向和冠状区域来估计泪腺体积,这比计算体积更简单,更省时。