PDF(Pubmed)
Abstract：
Limb regeneration in salamanders is achieved by a complex coordination of various biological processes and requires the proper integration of new tissue with old. Among the tissues found inside the limb, the skeleton is the most prominent component, which serves as a scaffold and provides support for locomotion in the animal. Throughout the years, researchers have studied the regeneration of the appendicular skeleton in salamanders both after limb amputation and as a result of fracture healing. The final outcome has been widely seen as a faithful re-establishment of the skeletal elements, characterised by a seamless integration into the mature tissue. The process of skeletal integration, however, is not well understood, and several works have recently provided evidence of commonly occurring flawed regenerates. In this Review, we take the reader on a journey through the course of bone formation and regeneration in salamanders, laying down a foundation for critically examining the mechanisms behind skeletal integration. Integration is a phenomenon that could be influenced at various steps of regeneration, and hence, we assess the current knowledge in the field and discuss how early events, such as tissue histolysis and patterning, influence the faithful regeneration of the appendicular skeleton.
摘要：
sal的肢体再生是通过各种生物过程的复杂协调来实现的，并且需要将新组织与旧组织适当整合。在肢体内部发现的组织中，骨架是最突出的组成部分，充当支架并为动物的运动提供支撑。多年来,研究人员研究了sal截肢后和骨折愈合后阑尾骨骼的再生。最终的结果被广泛认为是骨骼元素的忠实重建，以无缝整合到成熟组织为特征。骨骼整合的过程，然而,不是很了解，一些作品最近提供了证据，证明了常见的有缺陷的再生。在这篇评论中,我们带读者踏上了sal骨形成和再生过程的旅程，为批判性地研究骨骼整合背后的机制奠定了基础。整合是一种可能在再生的各个步骤中受到影响的现象，因此，我们评估该领域的当前知识，并讨论早期事件，如组织组织溶解和模式，影响阑尾骨骼的忠实再生。
