Abstract：
BACKGROUND: Pregnant women have physiological metabolic changes in glycemic and lipid profiles that are essential for fetal development.
OBJECTIVE: The aim of this systematic review was to analyze the effects of fish-oil-capsule supplementation on the glycemic and lipid profiles of pregnant women.
METHODS: A systematic search was conducted of the MEDLINE (by PubMed), Embase, Cochrane Library (CENTRAL) databases and gray literature, including preprints for all relevant studies published in English, with no date restrictions.
METHODS: The estimated pooled results were analyzed using a random-effects model and represented by mean differences (MDs) and corresponding 95% confidence intervals (CIs). The analyses were performed with R software, version 4.2.1, using the \"Meta\" packages, versions 6.0-0.
METHODS: Fifteen eligible studies were included after screening. In a pooled analysis, overall fish-oil supplementation had no effect on parameters compared with placebo. In the subgroup analysis, fish-oil supplementation may be beneficial in insulin (MD: -2.11 IU/mL; 95% CI: -3.86, -0.36) and homeostasis model assessment of insulin resistance (HOMA-IR) (MD: -0.71; 95% CI: -1.14, -0.29) indices, with heterogeneity (I2 =0%) among pregnant women with diabetes mellitus. In the subgroup with doses of eicosapentaenoic acid (EPA) below 200 mg, there was a reduction in HOMA-IR in the intervention group (MD: -0.60; 95% CI: -1.14, -0.06).
CONCLUSIONS: Pregnant women taking fish-oil capsules showed significant beneficial changes in the subgroups of type 2 diabetes and EPA dosages below 200 mg for insulin and HOMA-IR.
OBJECTIVE: The aim of this systematic review was to analyze the effects of fish-oil-capsule supplementation on the glycemic and lipid profiles of pregnant women.
METHODS: A systematic search was conducted of the MEDLINE (by PubMed), Embase, Cochrane Library (CENTRAL) databases and gray literature, including preprints for all relevant studies published in English, with no date restrictions.
METHODS: The estimated pooled results were analyzed using a random-effects model and represented by mean differences (MDs) and corresponding 95% confidence intervals (CIs). The analyses were performed with R software, version 4.2.1, using the \"Meta\" packages, versions 6.0-0.
METHODS: Fifteen eligible studies were included after screening. In a pooled analysis, overall fish-oil supplementation had no effect on parameters compared with placebo. In the subgroup analysis, fish-oil supplementation may be beneficial in insulin (MD: -2.11 IU/mL; 95% CI: -3.86, -0.36) and homeostasis model assessment of insulin resistance (HOMA-IR) (MD: -0.71; 95% CI: -1.14, -0.29) indices, with heterogeneity (I2 =0%) among pregnant women with diabetes mellitus. In the subgroup with doses of eicosapentaenoic acid (EPA) below 200 mg, there was a reduction in HOMA-IR in the intervention group (MD: -0.60; 95% CI: -1.14, -0.06).
CONCLUSIONS: Pregnant women taking fish-oil capsules showed significant beneficial changes in the subgroups of type 2 diabetes and EPA dosages below 200 mg for insulin and HOMA-IR.
摘要：
背景：孕妇在血糖和血脂方面有生理代谢变化，这对胎儿发育至关重要。
目的：本系统综述旨在分析补充鱼油胶囊对孕妇血糖和血脂的影响。
方法：对MEDLINE（PubMed）进行了系统搜索，Embase,Cochrane图书馆（CENTRAL）数据库和灰色文献，包括所有相关研究的英文预印本，没有日期限制。
方法：使用随机效应模型对估计的合并结果进行分析，并用均差（MD）和相应的95％置信区间（CI）表示。用R软件进行分析，版本4.2.1，使用“元”包，版本6.0-0。
方法：筛选后纳入15个符合条件的研究。在汇总分析中，与安慰剂相比,总鱼油补充对各参数无影响.在亚组分析中，补充鱼油可能有益于胰岛素（MD：-2.11IU/mL;95％CI：-3.86，-0.36）和胰岛素抵抗的稳态模型评估（HOMA-IR）（MD：-0.71;95％CI：-1.14，-0.29）指数，糖尿病孕妇之间具有异质性（I2=0％）。在二十碳五烯酸（EPA）剂量低于200mg的亚组中，干预组HOMA-IR降低(MD:-0.60;95%CI:-1.14,-0.06).
结论：服用鱼油胶囊的孕妇在2型糖尿病亚组中显示出明显的有益变化，EPA剂量低于200mg的胰岛素和HOMA-IR。
目的：本系统综述旨在分析补充鱼油胶囊对孕妇血糖和血脂的影响。
方法：对MEDLINE（PubMed）进行了系统搜索，Embase,Cochrane图书馆（CENTRAL）数据库和灰色文献，包括所有相关研究的英文预印本，没有日期限制。
方法：使用随机效应模型对估计的合并结果进行分析，并用均差（MD）和相应的95％置信区间（CI）表示。用R软件进行分析，版本4.2.1，使用“元”包，版本6.0-0。
方法：筛选后纳入15个符合条件的研究。在汇总分析中，与安慰剂相比,总鱼油补充对各参数无影响.在亚组分析中，补充鱼油可能有益于胰岛素（MD：-2.11IU/mL;95％CI：-3.86，-0.36）和胰岛素抵抗的稳态模型评估（HOMA-IR）（MD：-0.71;95％CI：-1.14，-0.29）指数，糖尿病孕妇之间具有异质性（I2=0％）。在二十碳五烯酸（EPA）剂量低于200mg的亚组中，干预组HOMA-IR降低(MD:-0.60;95%CI:-1.14,-0.06).
结论：服用鱼油胶囊的孕妇在2型糖尿病亚组中显示出明显的有益变化，EPA剂量低于200mg的胰岛素和HOMA-IR。
