PDF(Pubmed)
Abstract：
OBJECTIVE: To examine the relationship between habitual caffeinated beverage consumption and headache frequency, duration, and intensity in a prospective cohort of adults with episodic migraine.
BACKGROUND: Caffeine is a commonly ascribed headache trigger in adults with migraine and clinicians may counsel patients to avoid caffeinated beverages; however, few studies have examined this association.
METHODS: From March 2016 to August 2017, 101 adults with physician-confirmed episodic migraine completed baseline questionnaires, including information about caffeinated beverage consumption. For 6 weeks, they reported headache onset, duration, and pain intensity (scale 0-100) on twice-daily electronic diaries. Ninety-seven participants completed data collection. We examined associations between self-reported habitual caffeinated beverage consumption at baseline and headache outcomes prospectively captured over the following 6 weeks, adjusting for age, sex, and oral contraceptive use.
RESULTS: The adjusted mean headache days per month was similar among the 20 participants reporting no habitual intake (7.1 days, 95% confidence interval [CI] 5.1-9.2), the 65 participants reporting 1-2 servings/day (7.4 days, 95% CI 6.1-8.7), and the 12 participants reporting 3-4 servings/day (5.9 days, 95% CI 3.3-8.4). Similarly, mean headache duration (no servings/day: 8.6 h, 95% CI 3.8-13.3; 1-2 servings/day: 8.5 h, 95% CI 5.5-11.5; 3-4 servings/day: 8.8 h, 95% CI 2.3-14.9) and intensity (no servings/day: 43.8, 95% CI 37.0-50.5; 1-2 servings/day: 43.1, 95% CI 38.9-47.4; 3-4 servings/day: 46.5, 95% CI 37.8-55.3) did not differ across levels of caffeinated beverage intake, though estimates were imprecise.
CONCLUSIONS: We found no association between habitual caffeinated beverage intake and headache frequency, duration, or intensity. These data do not support a recommendation that patients with episodic migraine should avoid consuming caffeine. Further research is needed to understand whether deviating from usual caffeine intake may trigger migraine attacks.
BACKGROUND: Caffeine is a commonly ascribed headache trigger in adults with migraine and clinicians may counsel patients to avoid caffeinated beverages; however, few studies have examined this association.
METHODS: From March 2016 to August 2017, 101 adults with physician-confirmed episodic migraine completed baseline questionnaires, including information about caffeinated beverage consumption. For 6 weeks, they reported headache onset, duration, and pain intensity (scale 0-100) on twice-daily electronic diaries. Ninety-seven participants completed data collection. We examined associations between self-reported habitual caffeinated beverage consumption at baseline and headache outcomes prospectively captured over the following 6 weeks, adjusting for age, sex, and oral contraceptive use.
RESULTS: The adjusted mean headache days per month was similar among the 20 participants reporting no habitual intake (7.1 days, 95% confidence interval [CI] 5.1-9.2), the 65 participants reporting 1-2 servings/day (7.4 days, 95% CI 6.1-8.7), and the 12 participants reporting 3-4 servings/day (5.9 days, 95% CI 3.3-8.4). Similarly, mean headache duration (no servings/day: 8.6 h, 95% CI 3.8-13.3; 1-2 servings/day: 8.5 h, 95% CI 5.5-11.5; 3-4 servings/day: 8.8 h, 95% CI 2.3-14.9) and intensity (no servings/day: 43.8, 95% CI 37.0-50.5; 1-2 servings/day: 43.1, 95% CI 38.9-47.4; 3-4 servings/day: 46.5, 95% CI 37.8-55.3) did not differ across levels of caffeinated beverage intake, though estimates were imprecise.
CONCLUSIONS: We found no association between habitual caffeinated beverage intake and headache frequency, duration, or intensity. These data do not support a recommendation that patients with episodic migraine should avoid consuming caffeine. Further research is needed to understand whether deviating from usual caffeine intake may trigger migraine attacks.
摘要：
目的：研究习惯性含咖啡因饮料消费与头痛频率之间的关系，持续时间,和强度在成人发作性偏头痛的前瞻性队列中。
背景：咖啡因是成人偏头痛患者常见的头痛诱因，临床医生可能会建议患者避免使用含咖啡因的饮料；然而，很少有研究研究这种关联。
方法：从2016年3月至2017年8月，101名医生确认的发作性偏头痛成年人完成了基线调查问卷，包括有关含咖啡因饮料消费的信息。6周,他们报告头痛发作，持续时间,每天两次电子日记的疼痛强度（0-100级）。97名参与者完成了数据收集。我们检查了基线时自我报告的习惯性含咖啡因饮料消费与随后6周内前瞻性捕获的头痛结果之间的关联。调整年龄，性别,和口服避孕药的使用。
结果：在报告没有习惯性摄入的20名参与者中，调整后的每月平均头痛天数相似（7.1天，95%置信区间[CI]5.1-9.2)，65名参与者报告1-2份/天(7.4天，95%CI6.1-8.7)，12名参与者报告3-4份/天(5.9天，95%CI3.3-8.4）。同样，平均头痛持续时间（无份量/天：8.6小时，95%CI3.8-13.3；1-2份/天：8.5小时，95%CI5.5-11.5；3-4份/天：8.8小时，95％CI2.3-14.9）和强度（无份/天：43.8，95％CI37.0-50.5；1-2份/天：43.1，95％CI38.9-47.4；3-4份/天：46.5，95％CI37.8-55.3）在含咖啡因饮料摄入量水平之间没有差异，虽然估计不精确。
结论：我们发现习惯性含咖啡因饮料摄入量与头痛频率之间没有关联，持续时间,或强度。这些数据不支持建议发作性偏头痛患者应避免摄入咖啡因。需要进一步的研究来了解偏离通常的咖啡因摄入量是否会引发偏头痛发作。
结论：一些患者和医生认为咖啡因会导致偏头痛。我们研究了98名患有偏头痛的成年人，他们报告了他们通常喝多少咖啡因，并在六周内每天跟踪他们的头痛，我们发现人们每天喝的咖啡因饮料的数量与头痛的频率无关，持续时间,或疼痛程度。这些结果表明，发作性偏头痛患者不必避免饮用含咖啡因的饮料。
背景：咖啡因是成人偏头痛患者常见的头痛诱因，临床医生可能会建议患者避免使用含咖啡因的饮料；然而，很少有研究研究这种关联。
方法：从2016年3月至2017年8月，101名医生确认的发作性偏头痛成年人完成了基线调查问卷，包括有关含咖啡因饮料消费的信息。6周,他们报告头痛发作，持续时间,每天两次电子日记的疼痛强度（0-100级）。97名参与者完成了数据收集。我们检查了基线时自我报告的习惯性含咖啡因饮料消费与随后6周内前瞻性捕获的头痛结果之间的关联。调整年龄，性别,和口服避孕药的使用。
结果：在报告没有习惯性摄入的20名参与者中，调整后的每月平均头痛天数相似（7.1天，95%置信区间[CI]5.1-9.2)，65名参与者报告1-2份/天(7.4天，95%CI6.1-8.7)，12名参与者报告3-4份/天(5.9天，95%CI3.3-8.4）。同样，平均头痛持续时间（无份量/天：8.6小时，95%CI3.8-13.3；1-2份/天：8.5小时，95%CI5.5-11.5；3-4份/天：8.8小时，95％CI2.3-14.9）和强度（无份/天：43.8，95％CI37.0-50.5；1-2份/天：43.1，95％CI38.9-47.4；3-4份/天：46.5，95％CI37.8-55.3）在含咖啡因饮料摄入量水平之间没有差异，虽然估计不精确。
结论：我们发现习惯性含咖啡因饮料摄入量与头痛频率之间没有关联，持续时间,或强度。这些数据不支持建议发作性偏头痛患者应避免摄入咖啡因。需要进一步的研究来了解偏离通常的咖啡因摄入量是否会引发偏头痛发作。
结论：一些患者和医生认为咖啡因会导致偏头痛。我们研究了98名患有偏头痛的成年人，他们报告了他们通常喝多少咖啡因，并在六周内每天跟踪他们的头痛，我们发现人们每天喝的咖啡因饮料的数量与头痛的频率无关，持续时间,或疼痛程度。这些结果表明，发作性偏头痛患者不必避免饮用含咖啡因的饮料。
