PDF(Pubmed)
Abstract：
Lichen sclerosus (LS) is an uncommon, chronic, inflammatory mucocutaneous disorder found predominantly in females with unknown etiology. It presents as a white sclerotic plaque commonly located on the anogenital area. Extragenital LS is less prevalent, and LS affecting the oral mucosa is extremely rare, with only 39 biopsy-confirmed cases reported in the literature. Due to its several mimicking conditions, histological examination is usually required for a definitive diagnosis, particularly in patients with oral LS. Current evidence-based treatment recommendations for oral LS are unavailable; however, most cases tend to improve after treatment with topical or intralesional corticosteroids. We report a case of a 58-year-old female referred from the otolaryngology department for evaluating an asymptomatic whitish sclerotic plaque on the lower lip mucosa that had existed for 1 year. Following a punch biopsy, the patient was diagnosed with LS of labial mucosa. The condition improved after 2 months of treatment with topical and intralesional corticosteroids. The present case report raises awareness in recognizing oral LS and contributes to knowledge of this rare disorder.
摘要：
硬化性苔藓（LS）是一种罕见的，慢性，炎性皮肤粘膜疾病主要见于病因不明的女性。它表现为通常位于肛门生殖器区域的白色硬化斑块。婚外LS不那么普遍，影响口腔粘膜的LS非常罕见，文献中仅报道了39例活检确诊病例。由于它的几个模仿条件，组织学检查通常需要明确的诊断，特别是在口服LS患者中。目前尚无口服LS的循证治疗建议；然而，大多数病例在使用局部或病灶内皮质类固醇治疗后倾向于改善。我们报告了一例从耳鼻喉科转诊的58岁女性，用于评估存在1年的下唇粘膜上无症状的白色硬化斑块。穿刺活检后，患者被诊断为唇粘膜LS。局部和病灶内皮质类固醇治疗2个月后，病情改善。本病例报告提高了对口腔LS的认识，并有助于了解这种罕见疾病。
