PDF(Pubmed)
Abstract：
UNASSIGNED: Incisional hernia (IH) is a common complication after liver transplantation (LT) with an incidence rate of 5% to 46%. This retrospective study aimed to evaluate the risk factors for IH development after LT in the era of mammalian target of rapamycin (mTOR) inhibitors use.
UNASSIGNED: Data on patients who underwent LT between 2015 and 2021 were retrospectively reviewed. The patients were divided into 2 groups (IH group and non-IH group) according to the postoperative occurrence of IH.
UNASSIGNED: We analyzed data from 878 patients during the study period, with 28 patients (3.2%) developing IH. According to multivariate analysis, body mass index exceeding 25 kg/m2 and the use of mTOR inhibitors within the first month after LT were the sole significant factors for both IH occurrence and the subsequent need for repair operations. Notably, a history of wound complications, a Model for End-stage Liver Disease score, and the timing of LT-whether conducted during regular hours or at night-did not emerge as significant risk factors for IH after LT.
UNASSIGNED: Our study reveals a higher incidence of IH among obese patients following LT, often requiring surgical repair, particularly in cases involving mTOR inhibitor usage within the initial month after LT. Consequently, it is crucial to exercise increased vigilance, especially in obese patients, and exercise caution when considering early mTOR inhibitor administration after LT.
UNASSIGNED: Data on patients who underwent LT between 2015 and 2021 were retrospectively reviewed. The patients were divided into 2 groups (IH group and non-IH group) according to the postoperative occurrence of IH.
UNASSIGNED: We analyzed data from 878 patients during the study period, with 28 patients (3.2%) developing IH. According to multivariate analysis, body mass index exceeding 25 kg/m2 and the use of mTOR inhibitors within the first month after LT were the sole significant factors for both IH occurrence and the subsequent need for repair operations. Notably, a history of wound complications, a Model for End-stage Liver Disease score, and the timing of LT-whether conducted during regular hours or at night-did not emerge as significant risk factors for IH after LT.
UNASSIGNED: Our study reveals a higher incidence of IH among obese patients following LT, often requiring surgical repair, particularly in cases involving mTOR inhibitor usage within the initial month after LT. Consequently, it is crucial to exercise increased vigilance, especially in obese patients, and exercise caution when considering early mTOR inhibitor administration after LT.
摘要：
■切口疝（IH）是肝移植（LT）后常见的并发症，发生率为5％至46％。这项回顾性研究旨在评估哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂使用时代LT后IH发展的危险因素。
■对2015年至2021年接受LT的患者的数据进行回顾性分析。根据术后发生IH分为2组(IH组和非IH组)。
■我们分析了研究期间878名患者的数据，28例患者（3.2%）发展为IH。根据多变量分析，体重指数超过25kg/m2和LT后第一个月内使用mTOR抑制剂是IH发生和随后需要修复手术的唯一重要因素.值得注意的是,伤口并发症史,终末期肝病评分模型，LT的时间-无论是在常规时间还是在夜间进行-均未成为LT后IH的重要危险因素。
■我们的研究表明，LT术后肥胖患者的IH发生率更高，经常需要手术修复，特别是在LT后最初一个月内使用mTOR抑制剂的情况下。因此,提高警惕至关重要，尤其是肥胖患者，并在LT后考虑早期给予mTOR抑制剂时谨慎行事。
■对2015年至2021年接受LT的患者的数据进行回顾性分析。根据术后发生IH分为2组(IH组和非IH组)。
■我们分析了研究期间878名患者的数据，28例患者（3.2%）发展为IH。根据多变量分析，体重指数超过25kg/m2和LT后第一个月内使用mTOR抑制剂是IH发生和随后需要修复手术的唯一重要因素.值得注意的是,伤口并发症史,终末期肝病评分模型，LT的时间-无论是在常规时间还是在夜间进行-均未成为LT后IH的重要危险因素。
■我们的研究表明，LT术后肥胖患者的IH发生率更高，经常需要手术修复，特别是在LT后最初一个月内使用mTOR抑制剂的情况下。因此,提高警惕至关重要，尤其是肥胖患者，并在LT后考虑早期给予mTOR抑制剂时谨慎行事。
