PDF(Pubmed)
Abstract：
BACKGROUND: Clients want to know the ultimate cause of death in their pet after cancer treatment. The cause of euthanasia and investigation of urinary obstruction in treated dogs with urothelial carcinoma (UC) has not been specifically reported in veterinary literature.
OBJECTIVE: Our hypothesis was that the majority of treated dogs with UC are euthanized secondary to primary tumor factors, such as urinary obstruction.
METHODS: Fifty-nine client-owned dogs diagnosed with UC.
METHODS: Retrospective observational study on clinical signs and disease at euthanasia of dogs with UC treated by radiation therapy or chemotherapy or both.
RESULTS: The median overall survival time (OST) of all dogs was 339 days (range, 17-1996; 95% confidence interval [CI], 185-392; interquartile range [IQR], 112-505). Of dogs deemed to have been euthanized because of UC (50/59, 85%), the primary cause was considered to be local progression in 31/50 (62%), most often because of perceived complete or partial urinary obstruction (24/31, 77%). No variables were found to be predictive of urinary obstruction. The overall documented metastatic rate was 56%. In dogs euthanized because of UC, metastasis was deemed to be the cause in 19/50 (38%) dogs.
CONCLUSIONS: Regardless of the type of treatment, UC in dogs has a poor prognosis and there is a continuing need to improve treatments that focus on local control of the primary tumor, given its high contribution to the decision for euthanasia. Proactive management to avoid the high frequency of urinary obstruction may be worthy of future investigation.
OBJECTIVE: Our hypothesis was that the majority of treated dogs with UC are euthanized secondary to primary tumor factors, such as urinary obstruction.
METHODS: Fifty-nine client-owned dogs diagnosed with UC.
METHODS: Retrospective observational study on clinical signs and disease at euthanasia of dogs with UC treated by radiation therapy or chemotherapy or both.
RESULTS: The median overall survival time (OST) of all dogs was 339 days (range, 17-1996; 95% confidence interval [CI], 185-392; interquartile range [IQR], 112-505). Of dogs deemed to have been euthanized because of UC (50/59, 85%), the primary cause was considered to be local progression in 31/50 (62%), most often because of perceived complete or partial urinary obstruction (24/31, 77%). No variables were found to be predictive of urinary obstruction. The overall documented metastatic rate was 56%. In dogs euthanized because of UC, metastasis was deemed to be the cause in 19/50 (38%) dogs.
CONCLUSIONS: Regardless of the type of treatment, UC in dogs has a poor prognosis and there is a continuing need to improve treatments that focus on local control of the primary tumor, given its high contribution to the decision for euthanasia. Proactive management to avoid the high frequency of urinary obstruction may be worthy of future investigation.
摘要：
背景：客户想知道他们的宠物在癌症治疗后死亡的最终原因。在兽医文献中尚未具体报道安乐死的原因和对患有尿路上皮癌（UC）的狗的尿路梗阻的研究。
目的：我们的假设是，大多数接受治疗的UC犬在原发肿瘤因子后被安乐死，如尿路梗阻。
方法：59只被诊断为UC的客户饲养的狗。
方法：回顾性观察性研究，对接受放疗或化疗或两者治疗的UC犬安乐死的临床体征和疾病进行研究。
结果：所有狗的中位总生存时间（OST）为339天（范围，17-1996；95%置信区间[CI]，185-392；四分位数范围[IQR]，112-505).在被认为因UC而被安乐死的狗中（50/59，85％），主要原因被认为是31/50（62%）的局部进展，最常见的原因是感知到的完全或部分尿路梗阻（24/31，77％）。没有发现变量可以预测尿路梗阻。记录的总转移率为56%。因为UC而安乐死的狗，转移被认为是19/50（38％）狗的原因。
结论：无论治疗类型如何，狗的UC预后差，并且持续需要改善关注原发性肿瘤局部控制的治疗方法。鉴于它对安乐死的决定做出了巨大贡献。积极的管理，以避免尿路梗阻的高频率可能是值得未来研究。
目的：我们的假设是，大多数接受治疗的UC犬在原发肿瘤因子后被安乐死，如尿路梗阻。
方法：59只被诊断为UC的客户饲养的狗。
方法：回顾性观察性研究，对接受放疗或化疗或两者治疗的UC犬安乐死的临床体征和疾病进行研究。
结果：所有狗的中位总生存时间（OST）为339天（范围，17-1996；95%置信区间[CI]，185-392；四分位数范围[IQR]，112-505).在被认为因UC而被安乐死的狗中（50/59，85％），主要原因被认为是31/50（62%）的局部进展，最常见的原因是感知到的完全或部分尿路梗阻（24/31，77％）。没有发现变量可以预测尿路梗阻。记录的总转移率为56%。因为UC而安乐死的狗，转移被认为是19/50（38％）狗的原因。
结论：无论治疗类型如何，狗的UC预后差，并且持续需要改善关注原发性肿瘤局部控制的治疗方法。鉴于它对安乐死的决定做出了巨大贡献。积极的管理，以避免尿路梗阻的高频率可能是值得未来研究。
