UNASSIGNED: This study employed epidemiological, bacteriological, and multiple-locus variable-number tandem repeat analysis (MLVA) methods to conduct an epidemiological investigation, which is necessary for devising tailored control strategies.
UNASSIGNED: Between 1958 and 2022, 29,892 cases were reported, with an average annual number of cases and incidence of 467 and 7.1/100,000, respectively. The epidemic situation gradually worsened, with cases escalating from 26 cases in 2005 to 6,292 in 2022, with the incidence rate rising from 0.441 in 2005 to 86.83 in 2022. Geographically, the disease spread from a single affected county in 2004 to encompass all 22 counties in 2022. Yanchi County had the highest incidence, followed by the Hongsibao and Tongxin counties. These data suggest that Brucella infection has become a rampant regional concern in human brucellosis. Between 1958 and 2019, a total of 230 Brucella strains were identified across four studied hosts. These strains comprised four species with 12 biovars, including B. melitensis bv. 1, bv. 2, bv. 3, B. abortus bv. 1, bv. 3, bv. 4, bv. 5, bv. 6, bv. 7, B. suis bv. 1 and bv. 3, and B. canis. These data highlight the high species/biovars and host diversity of the Brucella population, posing a substantial challenge to brucellosis surveillance. There was an apparent transition from multiple species/biovars historically to the current dominance of a single species, B. melitensis, emphasizing the requirement for strengthening surveillance of B. melitensis. Genotypes 42 and 116, constituting 96.2% of the total number of genotypes, predominated in panel 1 and MLVA-11, indicating that all strains belong to the East Mediterranean lineage. MLVA cluster analysis revealed persistent transmission of dominant circulating genotypes, presenting an epidemic pattern characterized primarily by epidemiologically related cases with a few sporadic cases. Strains in this study exhibited high genetic homogeneity with strains from the Northwest, and those from Kazakhstan and Mongolia.
UNASSIGNED: The epidemic situation of human brucellosis has gradually worsened; the rampant epidemic of the disease has become a regional concern. The present study highlights that implementing the of targeted surveillance and intervention strategies is urge.
■这项研究采用了流行病学,细菌学,和多位点可变数串联重复分析(MLVA)方法进行流行病学调查,这对于设计定制的控制策略是必要的。
■在1958年至2022年之间,报告了29,892例,年平均病例数和发病率分别为467例和7.1/100,000例。疫情逐渐恶化,病例从2005年的26例上升到2022年的6,292例,发病率从2005年的0.441例上升到2022年的86.83例。地理上,该疾病在2004年从一个受影响的县传播到2022年的所有22个县.盐池县发病率最高,其次是红寺堡和同心县。这些数据表明,布鲁氏菌感染已成为人类布鲁氏菌病的普遍区域关注问题。在1958年至2019年之间,在四个研究宿主中总共鉴定出230株布鲁氏菌。这些菌株包括4个物种和12个生物品种,包括B.melitensisbv。1,BV。2、BV。3,B.abortusbv。1,BV。3,BV。4,BV。5,BV。6、BV。7,B.suisbv。1和BV。3和B.canis。这些数据突出了布鲁氏菌种群的高物种/生物多样性和寄主多样性,对布氏杆菌病监测构成重大挑战。从历史上的多个物种/生物物种明显过渡到当前的单个物种的主导地位,B.melitensis,强调了加强对蜂鸟监测的要求。基因型42和116,占基因型总数的96.2%,在图1和MLVA-11中占主导地位,表明所有菌株都属于东地中海谱系。MLVA聚类分析显示显性循环基因型的持续传播,呈现一种流行模式,其特征主要是流行病学相关病例和一些零星病例。本研究中的菌株与西北地区的菌株表现出高度的遗传同质性,来自哈萨克斯坦和蒙古。
■人类布鲁氏菌病的流行情况逐渐恶化;该疾病的猖獗流行已成为地区关注的问题。本研究强调,实施有针对性的监测和干预策略是当务之急。