PDF(Pubmed)
Abstract：
Intra-articular corticosteroids injections are a widely used treatment for pain from symptomatic osteoarthritis. Systematic reviews show that the treatment effect is modest compared with intra-articular saline (often considered as placebo) and lasts for 2-4 weeks on average. Potentially as a consequence of limited therapeutic duration, repeated injections are often given up to 4 injections annually. In this context of repeat injections, recent evidence has emerged that intra-articular corticosteroids might be associated with more MRI-assessed quantitative cartilage thickness loss than saline injections. Guidelines vary in the recommendation for use of intra-articular corticosteroids. Given the frequency with which intra-articular corticosteroids injections are used, the size and scale of the population with osteoarthritis, it is critical to fully understand the benefits and drawbacks of intra-articular corticosteroids injections. That is the focus of this debate article.
摘要：
关节内注射皮质类固醇是一种广泛使用的治疗症状性骨关节炎疼痛的方法。系统评价显示，与关节内盐水（通常被认为是安慰剂）相比，治疗效果适中，平均持续2-4周。可能是由于治疗持续时间有限，重复注射通常每年最多进行4次注射。在这种重复注射的情况下，最近的证据表明,关节内使用皮质类固醇可能与MRI评估的定量软骨厚度损失多于生理盐水注射相关.指南对关节内使用皮质类固醇的建议有所不同。鉴于关节内注射皮质类固醇的频率，骨关节炎人群的规模和规模，充分了解关节内注射皮质类固醇的利弊至关重要.这也是本文辩论的重点。
