PDF(Pubmed)
Abstract：
BACKGROUND: There are few cases of pulmonary granulomatous changes secondary to primary biliary cirrhosis (PBC). No case of granulomatous lung disease secondary to PBC misdiagnosed as lung cancer had been reported.
METHODS: A middle-aged woman presented with lung nodules and was misdiagnosed with lung cancer by positron emission tomography/computed tomography. She underwent left lobectomy, and the pathology of the nodules showed granulomatous inflammation, which was then treated with antibiotics. However, a new nodule appeared. Further investigation with lung biopsy and liver serology led to the diagnosis of PBC, and chest computed tomography indicated significant reduction in the pulmonary nodule by treatment with methylprednisolone and ursodeoxycholic acid.
CONCLUSIONS: Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.
METHODS: A middle-aged woman presented with lung nodules and was misdiagnosed with lung cancer by positron emission tomography/computed tomography. She underwent left lobectomy, and the pathology of the nodules showed granulomatous inflammation, which was then treated with antibiotics. However, a new nodule appeared. Further investigation with lung biopsy and liver serology led to the diagnosis of PBC, and chest computed tomography indicated significant reduction in the pulmonary nodule by treatment with methylprednisolone and ursodeoxycholic acid.
CONCLUSIONS: Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.
摘要：
背景：原发性胆汁性肝硬化（PBC）继发的肺肉芽肿改变很少。无一例PBC继发的肉芽肿性肺部疾病误诊为肺癌的报道。
方法：一名中年妇女表现为肺结节，正电子发射断层扫描/计算机断层扫描误诊为肺癌。她做了左叶切除术,结节的病理显示肉芽肿性炎症，然后用抗生素治疗。然而,一个新的结节出现了。肺活检和肝脏血清学的进一步检查导致了PBC的诊断，和胸部计算机断层扫描显示，甲基强的松龙和熊去氧胆酸治疗可明显减少肺结节。
结论：肺结节的诊断需要综合各种临床资料以避免不必要的肺叶切除术。
方法：一名中年妇女表现为肺结节，正电子发射断层扫描/计算机断层扫描误诊为肺癌。她做了左叶切除术,结节的病理显示肉芽肿性炎症，然后用抗生素治疗。然而,一个新的结节出现了。肺活检和肝脏血清学的进一步检查导致了PBC的诊断，和胸部计算机断层扫描显示，甲基强的松龙和熊去氧胆酸治疗可明显减少肺结节。
结论：肺结节的诊断需要综合各种临床资料以避免不必要的肺叶切除术。
