PDF(Pubmed)
Abstract：
UNASSIGNED: Nail psoriasis is a common condition that affects quality of life in individuals with psoriasis and psoriatic arthritis. Topical treatments have been shown to be effective in treating nail bed disease but not as effective in treating nail matrix diseases, which often requires intralesional corticosteroids.
UNASSIGNED: The objective of this open-label study was to evaluate the efficacy of combination calcipotriol/betamethasone dipropionate foam as a treatment for nail psoriasis including nail matrix disease.
UNASSIGNED: We report three patients with moderate to severe nail psoriasis with involvement of all ten fingernails who applied study foam nightly for 6 months. Nails were assessed using the NAPSI score evaluating both nail bed and nail matrix disease.
UNASSIGNED: NAPSI score improved including nail matrix disease in the majority of nails. No skin irritation or unexpected adverse events occurred.
UNASSIGNED: We conclude this foam combination product could be an effective and safe treatment for fingernail psoriasis and may provide better nail matrix penetration as evidenced by improvement in nail matrix score. Further studies are needed for additional evaluation.
UNASSIGNED: The objective of this open-label study was to evaluate the efficacy of combination calcipotriol/betamethasone dipropionate foam as a treatment for nail psoriasis including nail matrix disease.
UNASSIGNED: We report three patients with moderate to severe nail psoriasis with involvement of all ten fingernails who applied study foam nightly for 6 months. Nails were assessed using the NAPSI score evaluating both nail bed and nail matrix disease.
UNASSIGNED: NAPSI score improved including nail matrix disease in the majority of nails. No skin irritation or unexpected adverse events occurred.
UNASSIGNED: We conclude this foam combination product could be an effective and safe treatment for fingernail psoriasis and may provide better nail matrix penetration as evidenced by improvement in nail matrix score. Further studies are needed for additional evaluation.
摘要：
■指甲牛皮癣是一种常见病，会影响牛皮癣和银屑病关节炎患者的生活质量。局部治疗已被证明对治疗甲床疾病有效，但对治疗指甲基质疾病没有那么有效，通常需要病灶内皮质类固醇。
这项开放标签研究的目的是评估卡泊三醇/二丙酸倍他米松泡沫组合作为治疗包括指甲基质疾病的指甲牛皮癣的功效。
■我们报告了三名中度至重度指甲牛皮癣患者，所有十只指甲都在夜间应用研究泡沫6个月。使用NAPSI评分评估指甲床和指甲基质疾病。
■NAPSI评分改善，包括大多数指甲的指甲基质疾病。无皮肤刺激或意外不良事件发生。
■我们得出结论，这种泡沫组合产品可能是指甲牛皮癣的有效和安全的治疗方法，并且可以提供更好的指甲基质渗透，如指甲基质评分的改善所证明的。需要进一步的研究以进行额外的评估。
这项开放标签研究的目的是评估卡泊三醇/二丙酸倍他米松泡沫组合作为治疗包括指甲基质疾病的指甲牛皮癣的功效。
■我们报告了三名中度至重度指甲牛皮癣患者，所有十只指甲都在夜间应用研究泡沫6个月。使用NAPSI评分评估指甲床和指甲基质疾病。
■NAPSI评分改善，包括大多数指甲的指甲基质疾病。无皮肤刺激或意外不良事件发生。
■我们得出结论，这种泡沫组合产品可能是指甲牛皮癣的有效和安全的治疗方法，并且可以提供更好的指甲基质渗透，如指甲基质评分的改善所证明的。需要进一步的研究以进行额外的评估。
