PDF(Pubmed)
Abstract：
Acne is a chronic inflammatory disease of the pilosebaceous unit with a multifactorial etiology and is one of the most common conditions treated by dermatologists and primary care physicians. Within an extensive and evolving treatment landscape, oral isotretinoin has demonstrated efficacy for treatment of severe, recalcitrant acne. Several side effects of isotretinoin have been reported, including laboratory abnormalities, mucocutaneous, and musculoskeletal effects, which may reduce compliance and patient satisfaction with treatment. In this narrative review, we aim to review the efficacy and safety profile of oral supplements or topical adjuvant therapies in mitigating isotretinoin-associated mucocutaneous and musculoskeletal side effects. Oral supplements reviewed include omega-3 fatty acids, vitamin E, folic acid and vitamin B12, antihistamines, l-carnitine, biotin, and combined oral supplements. Topical adjuvants include a hyaluronic acid, biosaccharide gum-2, and glycerine gel-cream; a nongreasy, noncomedogenic, fragrance-free moisturizing cream; dexpanthenol; trichloroacetic acid; and a combination cream. Most of the supplements and topical adjuvants demonstrated efficacy with an adequate level of supporting evidence and no reported adverse events, indicating an adequate safety profile. Patients on isotretinoin may benefit from using oral supplements and topical adjuvants to minimize primarily mucocutaneous side effects, increase adherence to treatment, and thereby improve overall outcomes.
摘要：
痤疮是一种具有多因素病因的毛囊皮脂腺的慢性炎性疾病，是皮肤科医生和初级保健医生治疗的最常见病之一。在一个广泛而不断发展的治疗环境中，口服异维A酸已证明对治疗严重，顽固的痤疮。已经报道了异维甲酸的几种副作用，包括实验室异常，粘膜皮肤，和肌肉骨骼的影响，这可能会降低患者对治疗的依从性和满意度。在这篇叙述性评论中，我们的目的是回顾口服补充剂或局部辅助疗法在减轻与异维甲酸相关的粘膜皮肤和肌肉骨骼副作用方面的疗效和安全性.口服补充剂包括omega-3脂肪酸，维生素E,叶酸和维生素B12，抗组胺药，左旋肉碱,生物素,和联合口服补充剂。局部佐剂包括透明质酸，生物糖胶2和甘油凝胶乳膏；不油腻，非粉刺,无香料保湿霜；右泛醇；三氯乙酸；和组合霜。大多数补充剂和外用佐剂证明了疗效，具有足够的支持证据，没有报告的不良事件。表明足够的安全性。使用异维A酸的患者可能受益于使用口服补充剂和局部佐剂，以最大程度地减少粘膜皮肤副作用。增加对治疗的依从性，从而改善整体结果。
