PDF(Pubmed)
Abstract：
UNASSIGNED: It has been reported that coronavirus disease 2019 (COVID-19) may cause psychiatric disorders, but there are too many confounding factors in the various studies, making it difficult to draw accurate conclusions.
UNASSIGNED: We analyzed the clinical features and treatment of patients with non-severe COVID-19 who were hospitalized in neurology and psychiatry departments due to acute psychiatric disorders and performed a descriptive analysis.
UNASSIGNED: Of the 57 patients included, 65% were hospitalized in the neurology department. Eighty-two percent of the patients exhibited abnormal mental behavior 1 week or less after COVID-19 diagnosis, and more than 60% of the patients had normal electroencephalogram (EEG), head imaging, autoimmune encephalitis antibody, and cerebrospinal fluid (CSF) results. Abnormal EEG results included an increase in nonspecific slow waves, abnormal imaging results included small ischemic areas and lacunar infarctions, and abnormal CSF results included a slight increase in cell numbers and protein levels and an increase in pressure. After administering antipsychotic drugs and/or immunotherapy, 67% of the patients experienced improvement in their psychiatric disorders by the time of discharge. Thirty-nine percent of the patients were discharged without antipsychotic medication and experienced no relapse of psychiatric symptoms.
UNASSIGNED: Patients with non-severe COVID-19 and psychiatric disorders usually have a good prognosis and do not require long-term antipsychotic medication. Patients with uncontrollable mental symptoms experienced rapid remission after immunotherapy, suggesting that inflammation or the immune response may play an important role in the occurrence of simple acute psychiatric disorders caused by COVID-19.
UNASSIGNED: We analyzed the clinical features and treatment of patients with non-severe COVID-19 who were hospitalized in neurology and psychiatry departments due to acute psychiatric disorders and performed a descriptive analysis.
UNASSIGNED: Of the 57 patients included, 65% were hospitalized in the neurology department. Eighty-two percent of the patients exhibited abnormal mental behavior 1 week or less after COVID-19 diagnosis, and more than 60% of the patients had normal electroencephalogram (EEG), head imaging, autoimmune encephalitis antibody, and cerebrospinal fluid (CSF) results. Abnormal EEG results included an increase in nonspecific slow waves, abnormal imaging results included small ischemic areas and lacunar infarctions, and abnormal CSF results included a slight increase in cell numbers and protein levels and an increase in pressure. After administering antipsychotic drugs and/or immunotherapy, 67% of the patients experienced improvement in their psychiatric disorders by the time of discharge. Thirty-nine percent of the patients were discharged without antipsychotic medication and experienced no relapse of psychiatric symptoms.
UNASSIGNED: Patients with non-severe COVID-19 and psychiatric disorders usually have a good prognosis and do not require long-term antipsychotic medication. Patients with uncontrollable mental symptoms experienced rapid remission after immunotherapy, suggesting that inflammation or the immune response may play an important role in the occurrence of simple acute psychiatric disorders caused by COVID-19.
摘要：
■据报道，2019年冠状病毒病（COVID-19）可能会导致精神疾病，但是各种研究中存在太多混杂因素，很难得出准确的结论。
■我们分析了非重症COVID-19患者因急性精神疾病在神经内科和精神科住院的临床特征和治疗，并进行了描述性分析。
■在纳入的57名患者中，65%在神经内科住院。82%的患者在COVID-19诊断后1周或更短的时间内表现出异常的精神行为，超过60％的患者脑电图（EEG）正常，头部成像,自身免疫性脑炎抗体，和脑脊液（CSF）结果。异常脑电图结果包括非特异性慢波增加，异常的影像学结果包括小的缺血区和腔隙性梗塞，异常的CSF结果包括细胞数量和蛋白质水平的轻微增加以及压力的增加。在服用抗精神病药物和/或免疫疗法后，67％的患者在出院时经历了精神疾病的改善。39％的患者在没有抗精神病药物的情况下出院，并且没有出现精神症状的复发。
■患有非严重COVID-19和精神疾病的患者通常预后良好，不需要长期服用抗精神病药物。精神症状无法控制的患者在免疫治疗后迅速缓解，提示炎症或免疫反应可能在COVID-19引起的单纯急性精神疾病的发生中起重要作用。
■我们分析了非重症COVID-19患者因急性精神疾病在神经内科和精神科住院的临床特征和治疗，并进行了描述性分析。
■在纳入的57名患者中，65%在神经内科住院。82%的患者在COVID-19诊断后1周或更短的时间内表现出异常的精神行为，超过60％的患者脑电图（EEG）正常，头部成像,自身免疫性脑炎抗体，和脑脊液（CSF）结果。异常脑电图结果包括非特异性慢波增加，异常的影像学结果包括小的缺血区和腔隙性梗塞，异常的CSF结果包括细胞数量和蛋白质水平的轻微增加以及压力的增加。在服用抗精神病药物和/或免疫疗法后，67％的患者在出院时经历了精神疾病的改善。39％的患者在没有抗精神病药物的情况下出院，并且没有出现精神症状的复发。
■患有非严重COVID-19和精神疾病的患者通常预后良好，不需要长期服用抗精神病药物。精神症状无法控制的患者在免疫治疗后迅速缓解，提示炎症或免疫反应可能在COVID-19引起的单纯急性精神疾病的发生中起重要作用。
